Assessment of Oxidative Stress Parameters in Iraqi Male Patients with Covid-19; A Case Control Study.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2024-07-01 DOI:10.61186/rbmb.13.2.167

Zainab Nazar Hasan Anber, Basil Oied Saleh, Riyadh Hassan Majed

{"title":"Assessment of Oxidative Stress Parameters in Iraqi Male Patients with Covid-19; A Case Control Study.","authors":"Zainab Nazar Hasan Anber, Basil Oied Saleh, Riyadh Hassan Majed","doi":"10.61186/rbmb.13.2.167","DOIUrl":null,"url":null,"abstract":"Background: SARS-CoV-2 infection can cause significant alterations in our lives. Oxidative stress (OS) has been proposed to play a major role in COVID-19 pathogenesis, and the determination of OS biomarkers provides insight into disease severity.Methods: The study was conducted during the second wave of the pandemic in 2020. Fifty blood samples were collected from patients admitted to one of the COVID-19 isolation centers in Baghdad, Iraq. The samples were subdivided into 25 patients admitted to the intensive care unit (ICU) and 25 non-ICU patients, compared to 25 healthy controls. All participants were aged 35-52 years.Results: The study showed that the mean (±SD) serum total oxidant status (TOS) and malondialdehyde (MDA) levels were significantly increased (p< 0.001) in the ICU group compared to the control and non-ICU groups. Conversely, the levels of serum total antioxidant capacity (TAC) and serum antioxidative enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase, and glutathione (GSH) were significantly decreased (p< 0.001) in the ICU group compared to both the control and non-ICU groups. Serum zinc levels were significantly decreased (p< 0.001) in both ICU and non-ICU groups compared to the control group, while serum selenium (Se), copper (Cu), and vitamins C and E were significantly decreased (p< 0.001) in the ICU group compared to both the control and non-ICU groups.Conclusions: The presence of OS biomarkers in the sera of COVID-19 patients offers a potential new approach for the treatment of this disease.","PeriodicalId":45319,"journal":{"name":"Reports of Biochemistry and Molecular Biology","volume":"13 2","pages":"167-173"},"PeriodicalIF":1.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847586/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reports of Biochemistry and Molecular Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.61186/rbmb.13.2.167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: SARS-CoV-2 infection can cause significant alterations in our lives. Oxidative stress (OS) has been proposed to play a major role in COVID-19 pathogenesis, and the determination of OS biomarkers provides insight into disease severity.

Methods: The study was conducted during the second wave of the pandemic in 2020. Fifty blood samples were collected from patients admitted to one of the COVID-19 isolation centers in Baghdad, Iraq. The samples were subdivided into 25 patients admitted to the intensive care unit (ICU) and 25 non-ICU patients, compared to 25 healthy controls. All participants were aged 35-52 years.

Results: The study showed that the mean (±SD) serum total oxidant status (TOS) and malondialdehyde (MDA) levels were significantly increased (p< 0.001) in the ICU group compared to the control and non-ICU groups. Conversely, the levels of serum total antioxidant capacity (TAC) and serum antioxidative enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase, and glutathione (GSH) were significantly decreased (p< 0.001) in the ICU group compared to both the control and non-ICU groups. Serum zinc levels were significantly decreased (p< 0.001) in both ICU and non-ICU groups compared to the control group, while serum selenium (Se), copper (Cu), and vitamins C and E were significantly decreased (p< 0.001) in the ICU group compared to both the control and non-ICU groups.

Conclusions: The presence of OS biomarkers in the sera of COVID-19 patients offers a potential new approach for the treatment of this disease.

查看原文本刊更多论文

伊拉克男性新冠肺炎患者氧化应激指标评价病例对照研究。

背景：SARS-CoV-2感染会对我们的生活造成重大改变。氧化应激（OS）已被认为在COVID-19的发病机制中发挥重要作用，而氧化应激生物标志物的测定有助于了解疾病的严重程度。方法：本研究在2020年第二波大流行期间进行。从伊拉克巴格达一所新冠肺炎隔离中心收治的患者中采集了50份血液样本。样本被细分为25名入住重症监护病房（ICU）的患者和25名非ICU患者，与25名健康对照组相比。所有参与者年龄在35-52岁之间。结果：与对照组和非ICU组相比，ICU组患者血清总氧化状态（TOS）和丙二醛（MDA）水平的平均值（±SD）显著升高（p< 0.001）。相反，与对照组和非ICU组相比，ICU组血清总抗氧化能力（TAC）和血清抗氧化酶超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、过氧化氢酶和谷胱甘肽（GSH）水平均显著降低（p< 0.001）。与对照组相比，ICU组和非ICU组血清锌水平均显著降低（p< 0.001），而与对照组和非ICU组相比，ICU组血清硒（Se）、铜（Cu）、维生素C和E均显著降低（p< 0.001）。结论：COVID-19患者血清中OS生物标志物的存在为该疾病的治疗提供了一种潜在的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.