Cristian Marius Florea, Radu Ovidiu Rosu, Ioan Alexandru Minciuna, Gabriel Cismaru, Dana Pop, Ana-Maria Vlase, Iuliana Nenu, Gabriela Adriana Filip
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引用次数: 0
Abstract
Background: Atrial fibrillation is the most common human heart rhythm disorder, yet its underlying causes remain largely unknown. Trimethylamine N-oxide (TMAO), a by-product derived from the gut microbiota contributed by red meat, has been linked to numerous cardiovascular and metabolic diseases. Aims: This study aimed to evaluate the impact of serum TMAO levels on the occurrence of atrial fibrillation in patients with cardiovascular disease. Results: Utilizing a cross-sectional study design, fasting serum TMAO levels were measured and compared between 153 patients without cardiovascular disease and patients hospitalized for cardiovascular disease, stratified by the presence or absence of atrial fibrillation. While patients with more comorbidities had higher TMAO overall, the TMAO levels were not significantly different between cardiovascular disease patients with and without atrial fibrillation (p = 0.57). Moreover, there was no difference between atrial fibrillation progression phenotypes (p = 0.27). In multivariate analysis, a significant association was found with atherosclerotic cardiovascular disease (p = 0.04) and chronic kidney disease (p < 0.001), but there was no significant association between TMAO and atrial fibrillation (p = 0.9). Conclusions: Serum TMAO levels are not associated with the occurrence of atrial fibrillation and disease progression phenotypes in patients with cardiovascular disease, but are associated with ASCVD and CKD.
期刊介绍：
The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.
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