Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-02-24 DOI:10.1038/s41598-025-90104-1

Qiang Su, Jian Li, Yun Lu, Jiang Liang, Song Huang, Min Wu, Yuanli He, Zhenxiang An, Jinbing Ding, Zhizhong Zhang

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引用次数: 0

Abstract

Prior research has established the significance of spleen volume (SV) in the pathogenesis and advancement of ulcerative colitis (UC) and Crohn's disease (CD). Nevertheless, these investigations are predominantly observational, thereby leaving their causal associations ambiguous. Moreover, the breadth of existing research is constrained by various uncontrollable variables in clinical settings. This study aims to deduce the causal link between SV and the susceptibility to UC and CD through a genetic perspective. The objective of this study was to investigate the genetic association between SV and inflammatory bowel disease (IBD) risk using Mendelian randomization (MR) analysis. Single nucleotide polymorphisms (SNPs) associated with SV were used as instrumental variables. Genetic associations for UC and CD were extracted from the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), the FinnGen study, and other publicly available genome-wide association studies (GWAS). Methods such as inverse variance weighted, Bayesian weighted Mendelian randomization (BWMR), contamination mixture (ConMix), along with sensitivity analyses and the Steiger test were used in the study. A meta-analysis was conducted to synthesize the results. The study found that genetically predicted SV was associated with an increased risk of UC in the IIBDGC dataset (OR = 1. 223, 95% CI: 1. 055-1. 417, P = 0. 008), FinnGen (OR = 1. 169, 95% CI: 1. 003-1. 363, P = 0. 045), the GWAS study by Sakaue S (OR = 1. 188, 95% CI: 1. 008-1. 399, P = 0. 040), and in the meta-analysis (OR = 1. 115, 95% CI: 1. 014-1. 227, P = 0. 025). Similarly, genetically predicted SV was associated with an increased risk of CD in the IIBDGC dataset (OR = 1. 235, 95% CI: 1. 026-1. 488, P = 0. 026), FinnGen (OR = 1. 308, 95% CI: 1. 026-1. 667, P = 0. 030), the GWAS study by Zorina-Lichtenwalter K (OR = 1. 316, 95% CI: 1. 037-1. 670, P = 0. 024), and in the meta-analysis (OR = 1. 272, 95% CI: 1. 133-1. 428, P < 0. 001). According to the meta-analysis results, for each standard unit increase in SV, the risk of developing UC increases by 11. 5%, and the risk of developing CD increases by 27. 2%. This study presents findings that suggest a positive causal association between SV and the onset of IBD.

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脾脏体积与溃疡性结肠炎和克罗恩病的关系：孟德尔随机研究。

先前的研究已经确定脾脏体积（SV）在溃疡性结肠炎（UC）和克罗恩病（CD）的发病和进展中的重要意义。然而，这些调查主要是观察性的，因此使其因果关系模糊不清。此外，现有研究的广度受到临床环境中各种不可控变量的限制。本研究旨在从遗传学角度推断SV与UC和CD易感性之间的因果关系。本研究的目的是利用孟德尔随机化（MR）分析调查SV与炎症性肠病（IBD）风险之间的遗传关联。与SV相关的单核苷酸多态性（snp）被用作工具变量。UC和CD的遗传关联是从国际炎症性肠病遗传学联合会（IIBDGC）、FinnGen研究和其他公开的全基因组关联研究（GWAS）中提取的。研究中采用了方差反加权、贝叶斯加权孟德尔随机化（BWMR）、污染混合（ConMix）、敏感性分析和Steiger检验等方法。进行荟萃分析以综合结果。该研究发现，在IIBDGC数据集中，基因预测的SV与UC风险增加相关（OR = 1）。223, 95% ci: 1。055 - 1。p = 0。008), FinnGen (OR = 1；169, 95% ci: 1。003 - 1。p = 0。045)， Sakaue S的GWAS研究（OR = 1）。188, 95% ci: 1。008 - 1。399, p = 0。在荟萃分析中(OR = 1。115, 95% ci: 1。014 - 1。227, p = 0。025)。同样，在IIBDGC数据集中，基因预测的SV与CD风险增加相关（OR = 1）。235, 95% ci: 1。026 - 1。p = 0。026), FinnGen (OR = 1；308, 95% ci: 1。026 - 1。p = 0。030)， Zorina-Lichtenwalter K的GWAS研究（OR = 1）。316, 95% ci: 1。037 - 1。670 p = 0。在meta分析中(OR = 1。272, 95% ci: 1。133 - 1。428页

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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