Prognostic assessment of cervical cancer based on biomarkers: the interaction of ERRα and immune microenvironment.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2025-02-24 DOI:10.1186/s12985-025-02664-3

Meijin Zheng, Weifeng Huang, Dingjie Wang, Leyi Huang, Yuan Ren, Qiao Gao, Yuxuan Huang, Wenyu Lin, Lihua Chen

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引用次数: 0

Abstract

Background: Cervical cancer poses a substantial global health challenge. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. However, the effect of ERRα expression on cervical cancer prognosis and immune infiltration has not been explored. This study aims to clarify the expression pattern and role of ERRα in cervical cancer.

Methods: We analyzed ERRα expression and its clinical prognosis in cervical cancer using multiple databases, including The Cancer Genome Atlas (TCGA) and Tumor Immune Estimation Resource (TIMER). The results were further validated through immunohistochemistry (IHC) on 221 cervical cancer tissue samples. Furthermore, Kaplan-Meier and Cox regression analyses were used to assess the clinical significance of ERRα in cervical cancer patients. All calculations were performed using the R package.

Results: ERRα expression was significantly higher in cervical cancer tissues compared to normal tissues. High ERRα expression was associated with poor overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS). Multivariate Cox regression analysis confirmed ERRα as an independent prognostic factor. Additionally, ERRα expression correlated with various immune cell types and immune checkpoints, indicating its role in the tumor immune microenvironment.

Conclusions: ERRα emerges as a promising prognostic biomarker in cervical cancer, influencing immune cell infiltration and potentially guiding personalized therapeutic approaches. Future investigations are warranted to delineate the mechanistic pathways through which ERRα contributes to cervical cancer progression and to assess its viability as a target for innovative immunotherapy strategies.

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基于生物标志物的宫颈癌预后评估：ERRα与免疫微环境的相互作用。

背景：宫颈癌对全球健康构成重大挑战。雌激素相关受体α (ERRα)是与癌症预后不良相关的细胞能量代谢的中心调节因子。然而，ERRα表达对宫颈癌预后及免疫浸润的影响尚未探讨。本研究旨在阐明ERRα在宫颈癌中的表达模式及其作用。方法：应用cancer Genome Atlas （TCGA）和Tumor Immune Estimation Resource （TIMER）等数据库，分析ERRα在宫颈癌中的表达及其临床预后。通过221例宫颈癌组织样本的免疫组化（IHC）进一步验证了结果。应用Kaplan-Meier和Cox回归分析评价ERRα在宫颈癌患者中的临床意义。所有计算均使用R包进行。结果：ERRα在宫颈癌组织中的表达明显高于正常组织。高ERRα表达与较差的总生存期（OS）、疾病特异性生存期（DSS）和无进展生存期（PFS）相关。多因素Cox回归分析证实ERRα为独立预后因素。此外，ERRα的表达与多种免疫细胞类型和免疫检查点相关，表明其在肿瘤免疫微环境中的作用。结论：ERRα是一种有希望的宫颈癌预后生物标志物，影响免疫细胞浸润，并可能指导个性化治疗方法。未来的研究有必要描述ERRα促进宫颈癌进展的机制途径，并评估其作为创新免疫治疗策略靶点的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.