Aleksandra E Matusiak, Jan Stępniak, Krzysztof C Lewandowski, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
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引用次数: 0
Abstract
Background: Central hypothyroidism is characterized by either decreased TSH or, more commonly, normal TSH. This study aims to check whether this biochemical difference related to the severity of the pituitary disease, metabolic processes and general well-being. Methods: A retrospective analysis was performed on 108 inpatients with hypopituitarism, aged 18-80, hospitalized (1 January 2020, through 31 December 2022) in the Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland. Hypopituitary patients with central hypothyroidism (n = 90) were divided into two subgroups: patients with TSH below normal ranges (low TSH; n = 52) and patients with TSH in reference ranges (normal TSH; n = 38). Results: Among patients with central hypothyroidism, surgical treatment due to pituitary disease was performed more commonly in those with low TSH than in those with normal TSH (65 vs. 42%, p = 0.010). Expectedly, five pituitary deficiencies were diagnosed more commonly in patients with low TSH than in those with normal TSH (46 vs. 13%, p = 0.001). In a regression analysis, the ACTH concentration was the only independent determinant negatively associated with low TSH (also after limiting the analysis to non-treated patients). Regarding lipid profile, decreased HDL cholesterol occurred more commonly in patients with low TSH vs. normal TSH (44% vs. 23%; p = 0.033), which was also observed after the limitation to non-treated patients (47% vs. 21%; p = 0.013). Conclusions: Low TSH in patients with central hypothyroidism is associated with more advanced pituitary disease and less favorable metabolic profile.
MetabolitesBiochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍:
Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.