Integrated Macrogenomics and Metabolomics Analysis of the Effect of Sea Cucumber Ovum Hydrolysates on Dextran Sodium Sulfate-Induced Colitis.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-02-07 DOI:10.3390/md23020073

Shunmin Gong, Liqin Sun, Yongjun Sun, Wenming Ju, Gongming Wang, Jian Zhang, Xuejun Fu, Chang Lu, Yu Zhang, Wenkui Song, Mingbo Li, Leilei Sun

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引用次数: 0

Abstract

Inflammatory bowel disease remains a significant challenge in clinical settings. This study investigated the therapeutic potential of sea cucumber ovum hydrolysates (SCH) in a dextran sulfate sodium (DSS)-induced colitis mouse model. SCH, defined by its elevated stability and solubility, with a molecular weight below 1000 Da, significantly alleviated DSS-induced colitis, as evidenced by enhanced splenic index, reduced colonic damage, and diminished serum pro-inflammatory cytokines. Furthermore, macrogenomic analysis demonstrated that SCH increased beneficial gut microbes and decreased pro-inflammatory bacteria. Furthermore, metabolomic analysis of colonic tissues identified elevated levels of anti-inflammatory metabolites, such as Phenyllactate, 2-Hydroxyglutarate, and L-Aspartic acid, in colitis mice after oral administration of SCH. In conclusion, SCH represents a promising candidate for the treatment of colitis.

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海参卵水解物对右旋糖酐硫酸钠诱导结肠炎影响的综合宏观基因组学和代谢组学分析。

炎症性肠病仍然是临床环境中的一个重大挑战。本研究探讨海参卵水解物（SCH）对右旋糖酐硫酸钠（DSS）诱导的小鼠结肠炎模型的治疗作用。SCH具有较高的稳定性和溶解度，分子量低于1000 Da，可显著缓解dss诱导的结肠炎，表现为脾指数增强，结肠损伤减轻，血清促炎细胞因子降低。此外，宏观基因组分析表明，SCH增加了有益的肠道微生物，减少了促炎细菌。此外，结肠组织代谢组学分析发现，口服SCH后结肠炎小鼠的抗炎代谢物水平升高，如苯乳酸、2-羟戊二酸和l -天冬氨酸。总之，SCH是治疗结肠炎的有希望的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.