Exploring Phaeodactylum tricornutum for Nutraceuticals: Cultivation Techniques and Neurotoxin Risk Assessment.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-01-26 DOI:10.3390/md23020058

Tobias Ebbing, Lena Kopp, Konstantin Frick, Tabea Simon, Berit Würtz, Jens Pfannstiel, Ulrike Schmid-Staiger, Stephan C Bischoff, Günter E M Tovar

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Abstract

This study investigates the potential of the diatom Phaeodactylum tricornutum (PT) as a sustainable and nutritionally valuable food source, focusing on its ability to produce bioactive compounds such as eicosapentaenoic acid, fucoxanthin, chrysolaminarin (CRY) and proteins. PT was cultivated in a flat-plate airlift photobioreactor (FPA-PBR) illuminated with LEDs from two sides. The study aimed to monitor and minimize β-methylamino-L-alanine (BMAA) levels to address safety concerns. The data showed that the selected FPA-PBR setup was superior in biomass and EPA productivity, and CRY production was reduced. No BMAA was detected in any biomass sample during cultivation. By adjusting the cultivation conditions, PT biomass with different compositional profiles could be produced, enabling various applications in the food and health industries. Biomass from nutrient-repleted conditions is rich in EPA and Fx, with nutritional and health benefits. Biomass from nutrient-depleted conditions accumulated CRY, which can be used as dietary fiber. These results highlight the potential of PT as a versatile ingredient for human consumption and the effectiveness of FPA-PBRs with artificial lighting in producing high-quality biomass. This study also provides the basis for future research to optimize photobioreactor conditions to increase production efficiency and to tailor the biomass profiles of PT for targeted health-promoting applications.

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探索三角褐指藻营养品：培养技术和神经毒素风险评估。

本研究探讨了硅藻褐藻（Phaeodactylum tricornutum， PT）作为一种可持续的、有营养价值的食物来源的潜力，重点研究了其产生生物活性化合物的能力，如二十碳五烯酸、岩藻黄素、金蜡胺（chrysolaminarin， CRY）和蛋白质。PT在平板气升式光生物反应器（FPA-PBR）中培养，两侧有led照明。该研究旨在监测和最小化β-甲氨基- l -丙氨酸（BMAA）水平，以解决安全问题。结果表明，选择的FPA-PBR组合在生物量和EPA生产力方面具有优势，并降低了CRY产量。在培养过程中，所有生物质样品均未检测到BMAA。通过调整栽培条件，可以生产出不同成分的PT生物质，从而在食品和健康行业中得到不同的应用。来自营养充足条件的生物质富含EPA和Fx，具有营养和健康益处。营养枯竭条件下的生物质积累了可作为膳食纤维的CRY。这些结果突出了PT作为人类消费的多功能成分的潜力，以及fpa - pbr与人工照明在生产高质量生物质方面的有效性。该研究也为未来优化光生物反应器条件以提高生产效率和定制PT的生物量特征以实现有针对性的健康促进应用提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.