Association of the DRD and OXT Genetic Polymorphisms With Schizophrenia in a Chinese Population.

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Nervous and Mental Disease Pub Date : 2025-03-01 Epub Date: 2025-02-24 DOI:10.1097/NMD.0000000000001824

Jingjing Li, Wen Bi, Mengqiu Xiong, Lubanga Nasifu, Lingyun Zhang, Chengbin Zhu, Bangshun He

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引用次数: 0

Abstract

Abstract: The polymorphism of dopamine receptor (DRD) and oxytocin (OXT) may be associated with schizophrenia. A case-control study of 248 schizophrenia patients and 236 controls was conducted using the Sequenom MassARRAY platform. The results showed that DRD2 rs1800497 was a heterozygote (AG vs. GG: adjusted odds ratio [OR] = 1.88; 95% confidence interval [CI]: 1.09-3.25) and DRD3 rs7631540 (TC vs. CC: adjusted OR = 0.60; 95% CI: 0.36-1.02) may be associated with an increased risk of developing schizophrenia. In addition, the DRD2 rs1800497 genotype GA showed a reduced risk of schizophrenia in the male subgroup and the late-onset subgroup (>27 years of age). For DRD3 polymorphisms, the rs7631540 TC genotype was associated with schizophrenia in the female subgroup. In OXT polymorphism analysis, rs2740210 codominant CA/AA was a risk factor for schizophrenia in the male and early-onset subgroup (≤27 years old). This study also concluded that OXT rs2740210 codominant CA/AA is associated with schizophrenia.

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来源期刊

Journal of Nervous and Mental Disease 医学-精神病学

CiteScore

2.90

自引率

5.30%

发文量

233

审稿时长

3-8 weeks

期刊介绍： The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.