Isolated Inhibin-Producing Granulosa Cell Tumor Causing Primary Amenorrhea: A Case Report.

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of pediatric and adolescent gynecology Pub Date : 2025-02-22 DOI:10.1016/j.jpag.2025.02.006

Meridith P Pollie, Benjamin Peipert, Sarah Kim, Monica A Mainigi

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Abstract

Background: Juvenile granulosa cell tumors (JGCTs) are the most common pediatric ovarian sex cord-stromal tumor. Because most granulosa cell tumors are hormonally active, patients commonly present with signs and symptoms of endocrine dysfunction, including precocious puberty and menstrual irregularities. Most patients with JGCTs present with stage I disease confined to the ovary that can be managed with surgical excision alone with a favorable prognosis.

Case: A 15-year-old girl presented with primary amenorrhea. Evaluation revealed suppressed follicle-stimulating hormone, elevated luteinizing hormone, normal estradiol, and a markedly elevated inhibin B, and pelvic ultrasound and magnetic resonance imaging showed a mildly enlarged right ovary with a 1.6-cm "ovarian follicle." After consultation with gynecologic oncology, the patient underwent right salpingo-oophorectomy with histopathologic findings consistent with JGCT. Menarche subsequently occurred 2 months after surgery.

Summary and conclusion: Differences in GCT endocrine function, as well as the stage of pubertal development when the tumor develops, may lead to a variety of clinical presentations. It is important to consider inhibin-producing JGCT on the differential diagnosis for pediatric and adolescent patients presenting with amenorrhea.

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分离抑制素颗粒细胞肿瘤致原发性闭经1例。

背景：幼年颗粒细胞瘤（JGCT）是最常见的小儿卵巢性索间质肿瘤。由于大多数颗粒细胞瘤具有激素活性，患者通常会出现内分泌功能失调的症状和体征，包括性早熟和月经不调。大多数 JGCT 患者的 I 期病变局限于卵巢，只需手术切除即可，预后良好：病例：一名 15 岁女孩出现原发性闭经。盆腔 US 和 MRI 显示右侧卵巢轻度增大，有一个 1.6 厘米的 "卵泡"。妇科肿瘤科会诊后，患者接受了右侧输卵管切除术，组织病理学检查结果与 JGCT 一致。术后两个月月经初潮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pediatric and adolescent gynecology 医学-妇产科学

CiteScore

3.90

自引率

11.10%

发文量

251

审稿时长

57 days

期刊介绍： Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.