Fungal-Induced Hemophagocytic Lymphohistiocytosis: A Literature Review in Non-HIV Populations.

IF 4.2 2区生物学 Q2 MICROBIOLOGY

Journal of Fungi Pub Date : 2025-02-18 DOI:10.3390/jof11020158

Chia-Yu Chiu, Rachel S Hicklen, Dimitrios P Kontoyiannis

引用次数: 0

Abstract

We performed a thorough search of the literature published through December 2024 with no date exclusions on invasive fungal infection (IFI)-induced hemophagocytic lymphohistiocytosis (HLH) in non-human immunodeficiency virus (HIV) patients. The frequency of IFI-induced HLH reported across 16 articles was 9%. Of the 116 identified cases with available clinical information, 53% occurred in immunocompromised patients. IFIs were usually disseminated (76%), with Histoplasma capsulatum being the most common pathogen (51%). IFI and HLH were diagnosed simultaneously in most cases (78%). The 30-day survival rate was 64%. Reported cases had significant heterogeneity in patient characteristics, management strategies, and outcomes.

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我们对截至 2024 年 12 月发表的有关非人类免疫缺陷病毒（HIV）患者侵袭性真菌感染（IFI）诱导的嗜血细胞淋巴组织细胞增多症（HLH）的文献进行了全面检索，未排除日期限制。16 篇文章报道的 IFI 诱导的 HLH 发生率为 9%。在116例有临床资料的确定病例中，53%发生在免疫力低下的患者中。IFI通常呈播散性（76%），荚膜组织胞浆菌是最常见的病原体（51%）。大多数病例（78%）同时诊断出 IFI 和 HLH。30 天存活率为 64%。所报告的病例在患者特征、管理策略和治疗效果方面存在明显的异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fungi Medicine-Microbiology (medical)

CiteScore

6.70

自引率

14.90%

发文量

1151

审稿时长

11 weeks

期刊介绍： Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.