The Role of Necroptosis, Pyroptosis, and Ferroptosis in Porcine Intestinal Injury and Their Regulation by Nutrients and Bioactive Substances

Abstract

In the early stages of development, piglets exhibit immature intestinal morphology and function, rendering them susceptible to a range of internal and external stressors, such as viral and bacterial infection, and mycotoxin exposure, which causes intestinal damage. The intestinal damage is characterized by various types of cell death within intestinal epithelium. The traditional cell death types have been categorized as necrosis, apoptosis, and autophagy. However, recent research has identified several forms of novel regulated cell death (RCD) such as necroptosis, pyroptosis, and ferroptosis. A growing body of evidence has underscored the pivotal role of necroptosis, pyroptosis, and ferroptosis in intestinal damage in pigs. Moreover, intervention strategies have been shown to mitigate these 3 RCDs when pigs are exposed to excessive adverse factors. This review aims to elucidate the role of these emerging RCDs in intestinal damage and summarize current understanding of their regulation by nutrients and bioactive substances in pigs. Our goal was to provide future intervention strategies designed to alleviate intestinal damage in pigs.