Cardiovascular Outcomes in Hospitalized Patients with COVID-19: Does Age Really Matter?

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Development and Disease Pub Date : 2025-01-24 DOI:10.3390/jcdd12020041

Alex Sotomayor-Julio, Manuela Escalante, Yorlany Rodas-Cortes, Andrea Alejandra Arteaga-Tobar, Andrea Valencia, Fernando Wyss, Roger Martín Correa, Paola Oliver, Wilbert Yabar Galindo, Jessica Mercedes, Alejandra Inés Christen, Iván Criollo, Juan Martin Brunialti, Carlos Eduardo Montenegro, Pedro Schwartzmann, Eglee Castillo, Freddy Pow Chong, Claudia Almonte, Cesar Herrera, Juan Esteban Gomez-Mesa

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引用次数: 0

Abstract

Background: An advanced age elevates risk for COVID-19-related cardiovascular complications and mortality. This study analyzes cardiovascular comorbidities and outcomes in hospitalized COVID-19 patients across age groups to assess its impact.

Methods: The CARDIO COVID 19-20 registry is a prospective, multicenter cohort study of hospitalized SARS-CoV-2 patients across 44 institutions in 14 Latin American countries. Patients were categorized into four age groups, Group 1: under 40 years, Group 2: 40 to 64 years, Group 3: 65 to 79 years, and Group 4: 80 years or older.

Results: A total of 3260 patients were included. A total of 36.8% were women, and key comorbidities included overweight/obesity (49.7% [G1: 48.9%, G2: 56.3%, G3: 45.6%, G4: 32.7%]), and hypertension (49% [G1: 11.3%, G2: 40.3%, G3: 67.9%, G4: 80.4%]). Primary cardiovascular complications during hospitalization were arrhythmias (9.1% [G1: 3.4%, G2: 6.1%, G3: 14.9%, G4: 12.9%]), and acute heart failure (8.5% [G1: 3.6%, G2: 6.1%, G3: 12.1%, and G4: 15.2%]). In our cohort, 53.5% of the patients were admitted to the intensive care unit (G1: 49.2%, G2: 57%, G3: 55.3%, G4: 38.3%). In-hospital mortality rose significantly in patients aged 65 and older; G3: 334 (34.7%) and G4: 156 (45.6%) (p value: <0.001).

Conclusions: In Latin American COVID-19 patients, older age correlates with more comorbidities, cardiovascular complications, and higher in-hospital and 30-day mortality, indicating age as an independent mortality factor.

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来源期刊

Journal of Cardiovascular Development and Disease CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

12.50%

发文量

381