{"title":"Role of Random Skin Biopsies in the Diagnosis of Aortic Angiosarcoma.","authors":"Tomohiro Miyamura, Ken Yoshida, Taizo Shimomura, Toshikazu Miyakawa, Hitoshi Suzushima, Kenichiro Tanaka, Mio Ohshiro, Mayuko Moritsubo, Koichi Ohshima","doi":"10.2169/internalmedicine.4879-24","DOIUrl":null,"url":null,"abstract":"<p><p>Aortic angiosarcoma is an extremely rare malignancy that is often diagnosed postoperatively or during autopsy. We present a case that was diagnosed through random skin biopsy. A 75-year-old woman with Alzheimer's disease and chronic kidney disease presented with persistent fever and elevated C-reactive protein levels. Contrast-enhanced computed tomography showed irregular thickening of the aortic wall, which was initially suspected to be atherosclerosis. A random skin biopsy revealed tumor cells that were positive for vascular endothelial markers. The patient died 69 days later, with an autopsy confirming aortic angiosarcoma. Random skin biopsies may aid in the diagnosis of aortic angiosarcoma by detecting metastatic lesions when invasive procedures are not feasible.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2671-2675"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463408/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2169/internalmedicine.4879-24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Aortic angiosarcoma is an extremely rare malignancy that is often diagnosed postoperatively or during autopsy. We present a case that was diagnosed through random skin biopsy. A 75-year-old woman with Alzheimer's disease and chronic kidney disease presented with persistent fever and elevated C-reactive protein levels. Contrast-enhanced computed tomography showed irregular thickening of the aortic wall, which was initially suspected to be atherosclerosis. A random skin biopsy revealed tumor cells that were positive for vascular endothelial markers. The patient died 69 days later, with an autopsy confirming aortic angiosarcoma. Random skin biopsies may aid in the diagnosis of aortic angiosarcoma by detecting metastatic lesions when invasive procedures are not feasible.
期刊介绍：
Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine.
Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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