Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.

IF 3.4 Q2 INFECTIOUS DISEASES

Infectious Disease Reports Pub Date : 2025-02-06 DOI:10.3390/idr17010012

Julien A Clain, Morgane Picard, Henintsoa Rabezanahary, Sonia André, Steven Boutrais, Ella Goma Matsetse, Juliette Dewatines, Quentin Dueymes, Elise Thiboutot, Gina Racine, Calaiselvy Soundaramourty, Fabrizio Mammano, Pierre Corbeau, Ouafa Zghidi-Abouzid, Jérôme Estaquier

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Abstract

Background/objectives: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection.

Methods: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure.

Results: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV.

Conclusions: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.

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