Systematic gene expression analysis of putative target genes linked to miR-31 in 83 oral squamous cell carcinoma samples.

IF 2.4 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Head & Face Medicine Pub Date : 2025-02-25 DOI:10.1186/s13005-024-00443-z

Carolin Feldges, Susanne Jung, Nikolai Purcz, Christoph Sproll, Johannes Kleinheinz, Sonja Sielker

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引用次数: 0

Abstract

Background: The development of oral squamous cell carcinoma on the molecular level and the resulting prognosis for patients have remained poorly understood. While AngiomiR-31 was implicated in the progression and metastasis of OSCC. However, this connection has not yet been investigated in more detail and tested for its significance with regard to new therapies and the prognosis of patients.

Methods: Through a systemic analysis of putative target genes of AngiomiR-31 in OSCC, this study aimed to highlight possible prognostic markers and genes that might improve prognostic predictability in patients with oral squamous cell carcinoma, especially regarding AngiomiR-31 as an outstanding mediator of angiogenesis. The study is based on gene data from 83 OSCC samples. Potentially relevant genes were selected and sorted by TNM, grading and UICC in these 83 OSCC whole-genome microarray datasets. Data was analysed and tested for significance.

Results: Through our investigation 20 potential target genes, including tumor suppressor genes, oncogenes and genes not yet categorized, were found and their expression correlated significantly with the expression of AngiomiR-31.

Conclusion: These findings contribute to a more profound understanding of the molecular mechanisms underlying OSCC progression and may have implications for the development of novel therapeutic strategies targeting AngiomiR-31 in OSCC. Further validation of these genes is needed to validate their clinical relevance and potential as prognostic markers or therapeutic targets in OSCC.

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来源期刊

Head & Face Medicine DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.70

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： Head & Face Medicine is a multidisciplinary open access journal that publishes basic and clinical research concerning all aspects of cranial, facial and oral conditions. The journal covers all aspects of cranial, facial and oral diseases and their management. It has been designed as a multidisciplinary journal for clinicians and researchers involved in the diagnostic and therapeutic aspects of diseases which affect the human head and face. The journal is wide-ranging, covering the development, aetiology, epidemiology and therapy of head and face diseases to the basic science that underlies these diseases. Management of head and face diseases includes all aspects of surgical and non-surgical treatments including psychopharmacological therapies.