Systematic gene expression analysis of putative target genes linked to miR-31 in 83 oral squamous cell carcinoma samples.

IF 2.4 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Head & Face Medicine Pub Date : 2025-02-25 DOI:10.1186/s13005-024-00443-z

Carolin Feldges, Susanne Jung, Nikolai Purcz, Christoph Sproll, Johannes Kleinheinz, Sonja Sielker

{"title":"Systematic gene expression analysis of putative target genes linked to miR-31 in 83 oral squamous cell carcinoma samples.","authors":"Carolin Feldges, Susanne Jung, Nikolai Purcz, Christoph Sproll, Johannes Kleinheinz, Sonja Sielker","doi":"10.1186/s13005-024-00443-z","DOIUrl":null,"url":null,"abstract":"Background: The development of oral squamous cell carcinoma on the molecular level and the resulting prognosis for patients have remained poorly understood. While AngiomiR-31 was implicated in the progression and metastasis of OSCC. However, this connection has not yet been investigated in more detail and tested for its significance with regard to new therapies and the prognosis of patients.Methods: Through a systemic analysis of putative target genes of AngiomiR-31 in OSCC, this study aimed to highlight possible prognostic markers and genes that might improve prognostic predictability in patients with oral squamous cell carcinoma, especially regarding AngiomiR-31 as an outstanding mediator of angiogenesis. The study is based on gene data from 83 OSCC samples. Potentially relevant genes were selected and sorted by TNM, grading and UICC in these 83 OSCC whole-genome microarray datasets. Data was analysed and tested for significance.Results: Through our investigation 20 potential target genes, including tumor suppressor genes, oncogenes and genes not yet categorized, were found and their expression correlated significantly with the expression of AngiomiR-31.Conclusion: These findings contribute to a more profound understanding of the molecular mechanisms underlying OSCC progression and may have implications for the development of novel therapeutic strategies targeting AngiomiR-31 in OSCC. Further validation of these genes is needed to validate their clinical relevance and potential as prognostic markers or therapeutic targets in OSCC.","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"10"},"PeriodicalIF":2.4000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853977/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Face Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13005-024-00443-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The development of oral squamous cell carcinoma on the molecular level and the resulting prognosis for patients have remained poorly understood. While AngiomiR-31 was implicated in the progression and metastasis of OSCC. However, this connection has not yet been investigated in more detail and tested for its significance with regard to new therapies and the prognosis of patients.

Methods: Through a systemic analysis of putative target genes of AngiomiR-31 in OSCC, this study aimed to highlight possible prognostic markers and genes that might improve prognostic predictability in patients with oral squamous cell carcinoma, especially regarding AngiomiR-31 as an outstanding mediator of angiogenesis. The study is based on gene data from 83 OSCC samples. Potentially relevant genes were selected and sorted by TNM, grading and UICC in these 83 OSCC whole-genome microarray datasets. Data was analysed and tested for significance.

Results: Through our investigation 20 potential target genes, including tumor suppressor genes, oncogenes and genes not yet categorized, were found and their expression correlated significantly with the expression of AngiomiR-31.

Conclusion: These findings contribute to a more profound understanding of the molecular mechanisms underlying OSCC progression and may have implications for the development of novel therapeutic strategies targeting AngiomiR-31 in OSCC. Further validation of these genes is needed to validate their clinical relevance and potential as prognostic markers or therapeutic targets in OSCC.

查看原文本刊更多论文

83例口腔鳞状细胞癌样本中miR-31相关靶基因的系统基因表达分析

背景：口腔鳞状细胞癌在分子水平上的发展及其预后仍然知之甚少。而AngiomiR-31与OSCC的进展和转移有关。然而，这种联系尚未被更详细地调查和测试其在新疗法和患者预后方面的重要性。方法：本研究通过对OSCC中可能的AngiomiR-31靶基因的系统分析，旨在突出可能提高口腔鳞状细胞癌患者预后可预测性的预后标志物和基因，特别是关于血管生成的杰出介质AngiomiR-31。这项研究基于83个OSCC样本的基因数据。从83个OSCC全基因组微阵列数据集中选择可能相关的基因，并通过TNM、分级和UICC进行分类。对数据进行分析和显著性检验。结果：通过我们的调查，发现了20个潜在的靶基因，包括抑癌基因、致癌基因和尚未分类的基因，它们的表达与AngiomiR-31的表达有显著的相关性。结论：这些发现有助于更深入地了解OSCC进展的分子机制，并可能对开发针对AngiomiR-31的OSCC新治疗策略产生影响。需要进一步验证这些基因，以验证其临床相关性和作为OSCC预后标志物或治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Head & Face Medicine DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.70

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： Head & Face Medicine is a multidisciplinary open access journal that publishes basic and clinical research concerning all aspects of cranial, facial and oral conditions. The journal covers all aspects of cranial, facial and oral diseases and their management. It has been designed as a multidisciplinary journal for clinicians and researchers involved in the diagnostic and therapeutic aspects of diseases which affect the human head and face. The journal is wide-ranging, covering the development, aetiology, epidemiology and therapy of head and face diseases to the basic science that underlies these diseases. Management of head and face diseases includes all aspects of surgical and non-surgical treatments including psychopharmacological therapies.