{"title":"Nanogels-Innovative Drug Carriers for Overcoming Biological Membranes.","authors":"Lyubomira Radeva, Krassimira Yoncheva","doi":"10.3390/gels11020124","DOIUrl":null,"url":null,"abstract":"<p><p>Nanogels are promising drug delivery systems since they possess undeniable advantages such as high loading capacity for hydrophilic and hydrophobic drugs, stabilization of sensitive drugs, biocompatibility, and biodegradability. The present review summarizes experimental studies related to carriers, drug loading, and membrane transport of nanogels. In particular, the review discusses the properties, advantages, and limitations of polymeric carriers with respect to the behavior of the prepared nanogels in in vivo conditions. The potential of nanogel systems for encapsulation of hydrophilic or hydrophobic drugs and the mechanisms of loading and drug release are also emphasized. Moreover, the challenges related to nanogel transport through the barriers presented in parenteral, oral, ocular, nasal, and dermal routes of administration are also considered.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 2","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854394/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gels","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3390/gels11020124","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Nanogels are promising drug delivery systems since they possess undeniable advantages such as high loading capacity for hydrophilic and hydrophobic drugs, stabilization of sensitive drugs, biocompatibility, and biodegradability. The present review summarizes experimental studies related to carriers, drug loading, and membrane transport of nanogels. In particular, the review discusses the properties, advantages, and limitations of polymeric carriers with respect to the behavior of the prepared nanogels in in vivo conditions. The potential of nanogel systems for encapsulation of hydrophilic or hydrophobic drugs and the mechanisms of loading and drug release are also emphasized. Moreover, the challenges related to nanogel transport through the barriers presented in parenteral, oral, ocular, nasal, and dermal routes of administration are also considered.
期刊介绍：
The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts.
Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
