The effects of normobaric hypoxic resistance training on muscle strength in healthy adults.

IF 2.8 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-02-24 DOI:10.1007/s00421-025-05736-y

Hao Wang, Maiwulanjiang Tuerhongjiang, Zichen Zeng, Yi Wang, Jianxiu Liu, Ruidong Liu

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引用次数: 0

Abstract

Normobaric hypoxic resistance training (NHRT) has emerged as a novel approach to enhancing muscle strength, potentially offering advantages over conventional resistance training. However, its efficacy in healthy adults remains uncertain. This systematic review and meta-analysis aimed to evaluate the effects of NHRT on muscle strength indicators, including one-repetition maximum (1RM), isometric strength, and isokinetic strength, in healthy adults.

Methods: Following PRISMA 2020 guidelines, four databases (PubMed, Web of Science, SportDiscus, and CNKI) were searched from inception to October 25, 2024, for randomized controlled trials. Study quality was assessed using the Cochrane Risk of Bias tool. Effect sizes were calculated using Review Manager 5.4.

Results: A total of 22 RCTs involving 487 healthy adults were included. The meta-analysis revealed a significant small-to-moderate improvement in 1RM (SMD = 0.22, 95% CI [0.06, 0.38]) but no statistically significant effects on isometric strength (SMD = 0.32, 95% CI [-0.05, 0.70]) and isokinetic strength (SMD = 0.25, 95% CI [-0.11, 0.62]). Subgroup analyses indicated that oxygen concentrations of 14-16% and training loads of 60-80% 1RM produced the most substantial gains, particularly among untrained participants.

Conclusions: NHRT is a promising strategy for enhancing 1RM in healthy adults, with its effectiveness influenced by hypoxic levels, training load, and baseline training status. Optimal outcomes were observed at oxygen concentrations of 14-16% and moderate training loads (60-80% 1RM), particularly in untrained individuals. Further high-quality studies are warranted to confirm these outcomes and explore the underlying mechanisms.Registration number on PROSPEROCRD42024547100.

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.