Maternal vitamin D status during pregnancy in relation to childhood cardiometabolic risk factors: The GraviD-Child prospective cohort study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-22 DOI:10.1016/j.clnesp.2025.02.012

Anna Amberntsson , Linnea Bärebring , Mathilda Forsby , Anna Winkvist , Jenny M. Kindblom , Frida Dangardt , Hanna Augustin

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引用次数: 0

Abstract

Background & aims

In utero exposure to deficiencies of certain nutritional factors such as vitamin D has been related to adverse cardiometabolic outcomes in the offspring, but results are conflicting. The aim of this study was to investigate the association between maternal vitamin D status during pregnancy and markers of cardiometabolic risk in childhood.

Methods

Serum 25-hydroxyvitamin D (25OHD) concentrations were measured at 11- and 33-weeks’ gestation. At 7–8 years of age, the children were examined regarding anthropometry, body composition (by bioelectrical impedance), and blood pressure, and a blood sample was drawn. Cardiometabolic risk was assessed using individual cardiometabolic risk factors and a composite score of adiposity, blood pressure, blood lipids, and hemoglobin A1c, using age- and sex-specific z-scores. Associations between maternal vitamin D status in early and late pregnancy and z-scores of markers of cardiometabolic risk were evaluated using adjusted linear and logistic regression analyses.

Results

In total, n = 172 mother-child pairs were included. Neither was an association found between maternal 25OHD concentration with a composite score of cardiometabolic risk in childhood (Odds Ratio (OR) 1.02 (confidence interval (CI) 0.99–1.05), and OR 0.99 (CI 0.97–1.01) in early and late pregnancy, respectively), nor with any individual marker of cardiometabolic risk.

Conclusion

In conclusion, there were no evidence of an association between maternal vitamin D status during pregnancy and cardiometabolic risk factors in the child at 7–8 years of age.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.