Maternal vitamin D status during pregnancy in relation to childhood cardiometabolic risk factors: The GraviD-Child prospective cohort study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-22 DOI:10.1016/j.clnesp.2025.02.012

Anna Amberntsson , Linnea Bärebring , Mathilda Forsby , Anna Winkvist , Jenny M. Kindblom , Frida Dangardt , Hanna Augustin

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引用次数: 0

Abstract

Background & aims

In utero exposure to deficiencies of certain nutritional factors such as vitamin D has been related to adverse cardiometabolic outcomes in the offspring, but results are conflicting. The aim of this study was to investigate the association between maternal vitamin D status during pregnancy and markers of cardiometabolic risk in childhood.

Methods

Serum 25-hydroxyvitamin D (25OHD) concentrations were measured at 11- and 33-weeks’ gestation. At 7–8 years of age, the children were examined regarding anthropometry, body composition (by bioelectrical impedance), and blood pressure, and a blood sample was drawn. Cardiometabolic risk was assessed using individual cardiometabolic risk factors and a composite score of adiposity, blood pressure, blood lipids, and hemoglobin A1c, using age- and sex-specific z-scores. Associations between maternal vitamin D status in early and late pregnancy and z-scores of markers of cardiometabolic risk were evaluated using adjusted linear and logistic regression analyses.

Results

In total, n = 172 mother-child pairs were included. Neither was an association found between maternal 25OHD concentration with a composite score of cardiometabolic risk in childhood (Odds Ratio (OR) 1.02 (confidence interval (CI) 0.99–1.05), and OR 0.99 (CI 0.97–1.01) in early and late pregnancy, respectively), nor with any individual marker of cardiometabolic risk.

Conclusion

In conclusion, there were no evidence of an association between maternal vitamin D status during pregnancy and cardiometabolic risk factors in the child at 7–8 years of age.

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妊娠期间孕妇维生素D状况与儿童心脏代谢危险因素的关系：孕妇-儿童前瞻性队列研究

背景与目的：在子宫内暴露于某些营养因素如维生素D的缺乏与后代的不良心脏代谢结果有关，但结果相互矛盾。这项研究的目的是调查怀孕期间母亲维生素D水平与儿童时期心脏代谢风险标志物之间的关系。方法：测定妊娠11周和33周大鼠血清25-羟基维生素D （25OHD）浓度。在7-8岁时，对儿童进行人体测量、身体组成（通过生物电阻抗）和血压检查，并抽取血液样本。使用个体心脏代谢危险因素和肥胖、血压、血脂和血红蛋白A1c的综合评分来评估心脏代谢风险，使用年龄和性别特异性z评分。使用调整后的线性和逻辑回归分析评估孕妇妊娠早期和晚期维生素D状态与心脏代谢风险标记物z分数之间的关系。结果：共纳入n=172对母子。母体25OHD浓度与儿童期心脏代谢风险的综合评分（比值比（OR） 1.02（置信区间（CI） 0.99-1.05），妊娠早期和晚期的比值比分别为0.99 (CI 0.97-1.01)）和任何心脏代谢风险的个体标志物之间也没有关联。结论：总之，没有证据表明怀孕期间母亲维生素D水平与7-8岁儿童心脏代谢危险因素之间存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.