Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review.

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY

Case Reports in Gastroenterology Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.1159/000543679

Atul Shrestha, Sarah Elliott, Joshua Haron Abasszade, Kyle Wu, Thomas Worland, Ian Simpson, Anouk Dev

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Abstract

Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper.

Case presentation: We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper "wellness shots" leading to a significant drug-induced liver injury.

Conclusion: This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper's hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use.

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姜黄和胡椒碱相关的药物性肝损伤：一个病例和回顾。

简介：姜黄是一种常见的香料，用于传统的中国和阿育吠陀医学，有各种各样的健康益处。最近，人们开始关注姜黄引起的肝损伤，这与生物利用度增强的配方有关，通常包括黑胡椒中的胡椒碱。病例介绍：我们研究了一例40岁女性，在服用姜黄和黑胡椒“健康注射”后，疲劳、瘙痒和尿色加深，导致明显的药物性肝损伤。结论：该病例强调了认识草药（如姜黄）作为潜在肝毒性来源的迫切需要。尽管姜黄素以安全著称，但对其的监管和检测有限，可能意味着潜在的不良影响未得到充分认识。了解姜黄和黑胡椒肝毒性背后的机制，包括潜在遗传倾向的作用，需要进一步研究其安全使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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