Radiographic and Clinical Assessment of Unidirectional Porous Beta-Tricalcium Phosphate to Treat Benign Bone Tumors.

IF 3.4 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY
Toshiyuki Kunisada, Eiji Nakata, Tomohiro Fujiwara, Haruyoshi Katayama, Takuto Itano, Takanao Kurozumi, Teruhiko Ando, Toshifumi Ozaki
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Abstract

The purpose of this study was to evaluate radiographic changes, clinical outcomes, and complications following unidirectional porous beta-tricalcium phosphate (UDPTCP) implantation for the treatment of benign bone tumors. We retrospectively analyzed 46 patients who underwent intralesional resection. The patients were divided into two cohorts: Cohort 1 (n = 32), which included all bones except the phalanges and metacarpal/tarsal bones, and Cohort 2 (n = 14), which included the phalanges and metacarpal/tarsal bones. Radiographic changes were assessed at each reading based on resorption of the implanted UDPTCP and bone trabeculation through the defect. UDPTCP resorption and bone trabeculation were observed on radiographs within 3 months of surgery in all patients. Bone remodeling in the cavity progressed steadily for up to 3 years postoperatively. In Cohort 1, resorption and trabeculation progressed significantly in young patients, and trabeculation developed significantly in small lesions. The rates of resorption and trabeculation at 3 months postoperatively correlated statistically with their increased rates at one year. There was no statistical difference in resorption and trabeculation rates between Cohort 1 and Cohort 2. There were no cases of postoperative deep infections or allergic reactions related to the implant. UDPTCP is a useful bone-filling substitute for the treatment of benign bone tumors and has a low complication rate.

单向多孔β-磷酸三钙治疗良性骨肿瘤的放射学和临床评估
本研究的目的是评估单向多孔β -磷酸三钙(UDPTCP)植入治疗良性骨肿瘤后的影像学变化、临床结果和并发症。我们回顾性分析了46例行病灶内切除术的患者。患者被分为两组:队列1 (n = 32),包括除指骨和掌骨/跗骨外的所有骨骼;队列2 (n = 14),包括指骨和掌骨/跗骨。根据植入UDPTCP的吸收和骨小梁通过缺损的情况评估每次读数的影像学变化。所有患者术后3个月内的x线片均观察到UDPTCP的吸收和骨小梁形成。术后3年腔内骨重塑进展稳定。在队列1中,吸收和小梁在年轻患者中进展明显,小梁在小病变中发展明显。术后3个月的吸收率和骨小梁率与术后1年的增加率具有统计学上的相关性。队列1和队列2的吸收和小梁率无统计学差异。术后无一例深部感染或与种植体相关的过敏反应。UDPTCP是治疗良性骨肿瘤的一种有用的骨填充替代物,其并发症发生率低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomimetics
Biomimetics Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
3.50
自引率
11.10%
发文量
189
审稿时长
11 weeks
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