The long road to Ithaca: a physiologist's journey.

IF 5 2区 生物学 Q2 CELL BIOLOGY
Sadis Matalon
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Abstract

It was an honor to be asked to deliver the Walter B. Cannon Lecture during the 2024 American Physiological Summit meeting. Dr. Cannon served as president of the American Physiological Society from 1914-1916. He coined the term "fight or flight" to describe an animal's response to threats and the concept of Homeostasis. He was the consummate physician-scientist, an outstanding mentor and teacher, a prolific writer, and a humanitarian. The title of my lecture is based on a poem entitled "Ithaca," written by the Greek poet C. P. Cavafy, who recounts the 10 yr travels of Ulysses, from Troy to his home, Ithaca. Odysseus had to overcome many obstacles to survive this long journey. Like Odysseus, I encountered myriad of professional and health problems. But, I also have experienced the thrill of contributing to scientific knowledge, the satisfaction of watching my mentees develop into independent scientists, the excitement of teaching respiration physiology to medical and professional students, and the pleasure of being of service to my discipline by serving as Editor of the American Journal of Physiology-Lung Cellular and Molecular Physiology and of Physiological Reviews. During my career, I have been interested in identifying the basic mechanisms by which oxidant gases and pathogens damage the blood gas barrier resulting in acute and chronic lung injury. In this brief review, I summarize the results of current studies implicating free heme as a major mediator of acute lung injury and our efforts to develop recombinant forms of human hemopexin, as a countermeasure.

通往伊萨卡岛的漫漫长路:一位生理学家的旅程。
我很荣幸被邀请在2024年美国生理学高峰会议上发表沃尔特·b·坎农演讲。1914年至1916年,坎农博士担任美国生理学会主席。他创造了“战斗或逃跑”这个词来描述动物对威胁的反应和体内平衡的概念。他是一位完美的医生兼科学家,一位杰出的导师和教师,一位多产的作家,一位人道主义者。我演讲的题目是基于一首名为“伊萨卡”的诗,这首诗是希腊诗人c·p·卡瓦菲写的,他讲述了尤利西斯从特洛伊到他的家乡伊萨卡的十年旅行。奥德修斯必须克服许多障碍才能在这次长途旅行中幸存下来。像奥德修斯一样,我遇到了无数的职业和健康问题。但是,我也经历过为科学知识做出贡献的兴奋,看到我的学员成长为独立科学家的满足感,为医学和专业学生教授呼吸生理学的兴奋,以及作为《美国生理学杂志-肺细胞和分子生理学》和《生理学评论》的编辑为我的学科服务的乐趣。在我的职业生涯中,我一直对确定氧化气体和病原体破坏血气屏障导致急性和慢性肺损伤的基本机制感兴趣。在这篇简短的综述中,我总结了目前的研究结果表明游离血红素是急性肺损伤的主要介质,以及我们为开发重组形式的人血凝素作为对策所做的努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.10
自引率
1.80%
发文量
252
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.
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