Total histamine degrading capacity: Correlation to stool histamine and its usefulness in supporting the diagnosis of histamine intolerance

IF 2.6 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Analytical biochemistry Pub Date : 2025-02-22 DOI:10.1016/j.ab.2025.115819

Gabriele Frost , Christian Lutz , Andreas Schwiertz , Hermann Huber , Albert Missbichler

{"title":"Total histamine degrading capacity: Correlation to stool histamine and its usefulness in supporting the diagnosis of histamine intolerance","authors":"Gabriele Frost , Christian Lutz , Andreas Schwiertz , Hermann Huber , Albert Missbichler","doi":"10.1016/j.ab.2025.115819","DOIUrl":null,"url":null,"abstract":"<div><div>The relatively new test (European Patent granted 2022) for determining the total histamine degradation capacity [Totale Histamin Abbau Kapazität/Total Histamine Degrading Capacity] THAK®/THDC of a serum sample has been compared in various settings with the individual clinical history and the levels of histamine in stool. The measurement of THAK can be carried out regardless of the current status of the patient (independent of any acute symptoms), therefore THAK test is a useful and very reliable instrument for supporting the diagnosing histamine intolerance. As soon as the THAK falls below a threshold value the patient is most likely to suffer from HIT, even if the intensity of the symptoms is low. Low THAK values correspond with a significant increase of histamine in stool. Results were evaluated according to both age and gender, no difference between the sexes were found. However, there is a noticeable dependency on age, although this is not diagnostically relevant.</div><div>THAK® is a registered trademark of Frost Diagnostika.</div></div>","PeriodicalId":7830,"journal":{"name":"Analytical biochemistry","volume":"702 ","pages":"Article 115819"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical biochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003269725000570","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

The relatively new test (European Patent granted 2022) for determining the total histamine degradation capacity [Totale Histamin Abbau Kapazität/Total Histamine Degrading Capacity] THAK®/THDC of a serum sample has been compared in various settings with the individual clinical history and the levels of histamine in stool. The measurement of THAK can be carried out regardless of the current status of the patient (independent of any acute symptoms), therefore THAK test is a useful and very reliable instrument for supporting the diagnosing histamine intolerance. As soon as the THAK falls below a threshold value the patient is most likely to suffer from HIT, even if the intensity of the symptoms is low. Low THAK values correspond with a significant increase of histamine in stool. Results were evaluated according to both age and gender, no difference between the sexes were found. However, there is a noticeable dependency on age, although this is not diagnostically relevant.

THAK® is a registered trademark of Frost Diagnostika.

查看原文本刊更多论文

总组胺降解能力：与粪便组胺的相关性及其在支持组胺不耐受诊断中的有用性。

测定血清样本的总组胺降解能力的相对较新的测试（欧洲专利授予2022）[Totale Histamin Abbau Kapazität / total histamine degradation capacity] THAK®/THDC已在不同环境下与个人临床病史和粪便中组胺水平进行了比较。无论患者的当前状态如何（独立于任何急性症状），都可以进行THAK的测量，因此THAK测试是支持诊断组胺不耐受的有用且非常可靠的工具。一旦THAK低于阈值，即使症状强度较低，患者也很可能患有HIT。较低的THAK值对应于粪便中组胺的显著增加。结果根据年龄和性别进行评估。没有发现性别之间的差异。然而，有一个明显的依赖于年龄，虽然这不是诊断相关。THAK®是Frost diagnostics的注册商标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Analytical biochemistry 生物-分析化学

CiteScore

5.70

自引率

0.00%

发文量

283

审稿时长

44 days

期刊介绍： The journal''s title Analytical Biochemistry: Methods in the Biological Sciences declares its broad scope: methods for the basic biological sciences that include biochemistry, molecular genetics, cell biology, proteomics, immunology, bioinformatics and wherever the frontiers of research take the field. The emphasis is on methods from the strictly analytical to the more preparative that would include novel approaches to protein purification as well as improvements in cell and organ culture. The actual techniques are equally inclusive ranging from aptamers to zymology. The journal has been particularly active in: -Analytical techniques for biological molecules- Aptamer selection and utilization- Biosensors- Chromatography- Cloning, sequencing and mutagenesis- Electrochemical methods- Electrophoresis- Enzyme characterization methods- Immunological approaches- Mass spectrometry of proteins and nucleic acids- Metabolomics- Nano level techniques- Optical spectroscopy in all its forms. The journal is reluctant to include most drug and strictly clinical studies as there are more suitable publication platforms for these types of papers.