Prevalence and factors associated with dementia in Lesotho: A cross-sectional, population-based study

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-02-25 DOI:10.1002/alz.14614

Natalie E. Johnson, Jennifer M. Belus, Felix Gerber, Tristan T. Lee, Irene Ayakaka, Pearl Letsoela, Manthabiseng Molulela, Frédérique Chammartin, Alain Amstutz, Niklaus D. Labhardt

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Abstract

INTRODUCTION

Limited research has examined dementia prevalence and associated factors in Lesotho. This study investigates dementia prevalence and the associated factors in Lesotho.

METHODS

A survey in Lesotho included 1738 participants screened for dementia and potential associated factors with a focus on modifiable factors. Associations were evaluated using logistic regression models.

RESULTS

The median age was 66 years, with 54.83% women. The prevalence of dementia was 4.89%. Those with depressive symptoms (adjusted odds ratio [aOR]: 3.97, 95% confidence interval [CI]: 1.39–11.30), age ≥ 75 (aOR: 2.68, 95% CI: 1.42–5.04), and underweight (aOR 2.30, 95% CI: 1.23–4.29) had increased odds of dementia. Those with moderate (aOR: 0.32, 95% CI: 0.17–0.58) to high (aOR: 0.35, 95% CI: 0.16–0.77) physical activity and obesity (aOR: 0.30, 95% CI: 0.11–0.80) presented lower odds for dementia.

DISCUSSION

This study provides a contemporary estimate of dementia prevalence in Lesotho, highlighting an association with modifiable factors.

Highlights

In Lesotho there is a probable dementia prevalence of 4.89%, aligning with regional estimates for Africa.
Depression, older age, being underweight, and low physical activity were associated with increased odds of dementia.
Moderate to high physical activity and obesity were associated with lower dementia odds.
Further study of the association of dementia with potentially modifiable factors in low- and middle-income countries is warranted.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.