Mesoporous Bioactive Glass-Based Composite Cryogel for Noncompressible Hemorrhage

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Jie Zhou, Yang Liu, Changren Mo, Kun Yang, Guangyu Zhang
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引用次数: 0

Abstract

Uncontrollable bleeding is one of the important causes of death in war, road traffic injuries, surgical accidents, and other accidents. Using hemostatic materials to control bleeding quickly and effectively can improve the survival rate of patients, especially for incompressible visceral bleeding. Traditional inorganic materials and natural polymers alone still have limitations, such as non-degradability and ineffective control of bleeding through wounds. In this work, we designed a cryogel sponge combined Mesoporous bioactive glass (MBG) with Gelatin Methacryloyl (GelMA), which has enhanced mechanical strength and improved in vitro coagulation properties. And MBG@GelMA cryogel could absorb water more than 5 times in 5 min, while it also demonstrates significant improvement in mechanical strength from 4 kap to 12 kpa. Additionally, MBG@GelMA cryogel showed excellent biocompatibility and hemostatic performance. The multi-stage pore structure and hydrophilicity of frozen gel and MBG help to concentrate blood quickly and activate endogenous coagulation pathway through the release of calcium ions to promote coagulation. The findings of this study demonstrate that the MBG@GelMA composite cryogel possesses outstanding properties in terms of hemostasis, portability, and ease of use, suggesting its remarkable potential as a promptly applicable hemostatic material in both civil and military settings.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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