Centrosome biogenesis and maintenance in homeostasis and disease

Abstract

Recent technological advances in proteomics and microscopy techniques, such as cryo-electron microscopy (cryoEM) and expansion microscopy (ExM), have enhanced our understanding of centrosome structure, biogenesis, and regulation. Here we discuss new insights into centrosome structure, highlight new regulatory mechanisms in centrosome biogenesis, and explore emerging concepts in centrosome maintenance and plasticity across different contexts. Furthermore, we review how centrosome biogenesis and homeostasis are dysregulated in various pathological conditions. We finalise by outlining outstanding questions in the field, how the mechanisms discussed are regulated across multiple contexts, the balance between centriole stability and plasticity, and the therapeutic potential of targeting centrosome dysfunction in disease.