Primary infertile couples share more HLA alleles than expected by chance

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-02-24 DOI:10.1016/j.ejogrb.2025.02.053

David Göhring , Maren Goeckenjan , Inés Göhring , Vinzenz Lange , Jürgen Sauter , Denise Kreßner-Kiel , Alexander H. Schmidt , Ilona Croy

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引用次数: 0

Abstract

Objective

To examine whether the rate of HLA similarity among 609 primarily infertile couples is higher than would be expected by chance.

Design

Clinical Trial.

Subjects

609 primary infertile couples (mean age women: 34.35 years, men: 37.59 years) were recruited before undergoing IVF or ICSI therapy. Couples with former pregnancies, tubal factor, azoospermia or donor therapies were excluded.

Intervention

For each of the partners, exons encoding the corresponding antigen recognition sites of HLA-A, −B, −C, −DRB1, −DQB1, and −DPB1 were sequenced by using next-generation sequencing. HLA similarity between partners was determined based on the probability of homozygous offspring and the observed probability of heterozygous offspring in the sample of primary infertile couples was comparted to the probability for random pairing using bootstrapping.

Main outcome measures

HLA similarity of infertile couples compared to randomly assigned couples.

Results

In each of the loci, infertile pairs shared more alleles than expected by chance. This result was significant for all HLA class 2 loci (−DRB1, −DQB1, −DPB1), as well as for the HLA class I locus −C, while HLA-A and −B showed a nonsignificant trend towards higher similarity.

Conclusion

These data suggest that HLA similarity between couples relates to primary infertility.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.