Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2025-02-21 DOI:10.1016/j.archger.2025.105787

Xiangpeng Meng , Ze Wang , Linyu Lyu

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引用次数: 0

Abstract

Purpose

Recent research has reported a potential bidirectional association between sarcopenia and depression, yet systematic evidence supporting this relationship is still lacking. This study evaluated the bidirectional association of sarcopenia with depression to provide reliable evidence for the development of specific prevention and control strategies.

Methods

Relevant articles were extracted from PubMed, Embase, Cochrane, and Web of Science from inception to July 4, 2024. Quality was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, and the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional studies. Changes in the association between sarcopenia and depression were compared across different study designs, sources of study subjects, and sarcopenia diagnostic criteria by subgroup analyses. Meta-analysis was conducted using R 4.4.1.

Results

Thirty-three original studies involving 119,421 subjects were incorporated into this review. Pooled analysis revealed a significant reciprocal relationship between sarcopenia and depression in community populations. The risk of depression increased when sarcopenia was the exposure factor [OR = 2.40(95 % CI: 1.87, 3.08)]. Conversely, the risk of sarcopenia significantly increased when depression was the exposure factor [OR = 1.90(95 % CI: 1.44, 2.50)]. Additionally, there was a markedly increased risk of sarcopenia when depressive symptoms were the exposure factor [OR = 1.38(95 % CI: 1.25, 1.53)]. Similar conclusions were obtained in patients with other diseases.

Conclusions

The significant bidirectional association between sarcopenia and depression enhances the prevention, screening, diagnosis, and treatment of depression, thereby improving quality of life and outcomes.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.