Dynamic regulation of cortical interneuron wiring

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-02-26 DOI:10.1016/j.conb.2025.102980

Claudia Rosés-Novella , Clémence Bernard

引用次数: 0

Abstract

Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must adapt to changes in cortical activity and environmental information to drive appropriate responses. In this review, we focus on the latest progress in our understanding of the processes that regulate interneuron wiring adaptability. We discuss newly identified types of regulatory processes, from structural synaptic changes to long-range neuromodulation, and provide an update on the activity-dependent molecular underpinnings at the transcriptional and post-transcriptional levels.

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皮层神经元间连线的动态调节

抑制性中间神经元在调节大脑皮层的回路和活动模式中起着至关重要的作用。特别是，中间神经元必须适应皮层活动和环境信息的变化，以驱动适当的反应。在这篇综述中，我们重点介绍了调控中间神经元布线适应性的过程的最新进展。我们讨论了新发现的调节过程类型，从结构突触变化到远程神经调节，并提供了在转录和转录后水平上活动依赖的分子基础的更新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience