Synthesis and characterization of magneto-optical bifunctional Fe3O4/Gd2O3:Tb3+@SiOx nanocomposites for enhanced MR imaging

IF 3.9 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Science and Engineering: B Pub Date : 2025-02-26 DOI:10.1016/j.mseb.2025.118162

Wuxiong Chen , Hao Zhou , Meigui Ou , Jiarong Zhang , Chunlin Yang

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引用次数: 0

Abstract

Gadolinium- and iron-based contrast agents (CA) have historically been the most commonly utilized MR imaging CA. However, the potential toxicity of metallic substances presents an obvious drawback. In this paper, magneto-optical bifunctional Fe₃O₄/Gd₂O₃:Tb³⁺@SiOx nanocomposites were synthesized via co-precipitation and polyol method. The biocompatibility and dispersibility of Fe₃O₄/Gd₂O₃:Tb³⁺ were improved by covering the outer side with a layer of SiOx. The effects of various synthesis temperatures on the properties of the composites were investigated. It was found that with the increase of synthesis temperature, the average particle size of Fe₃O₄/Gd₂O₃:Tb³⁺@SiOx crystal increased from 15 to 23 nm and the saturation magnetization decreased from 13.734 to 10.623 emu/g. Higher luminescence and magnetic intensity are observed in the nanocomposites synthesized at 25 °C due to the enhanced crystallinity and size uniformity. Finally, in vitro cytotoxicity and in vivo MR images in SD mice demonstrated the excellent biocompatibility and high-resolution MR imaging of Fe₃O₄/Gd₂O₃:Tb³⁺@SiOx.

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来源期刊

Materials Science and Engineering: B 工程技术-材料科学：综合

CiteScore

5.60

自引率

2.80%

发文量

481

审稿时长

3.5 months

期刊介绍： The journal provides an international medium for the publication of theoretical and experimental studies and reviews related to the electronic, electrochemical, ionic, magnetic, optical, and biosensing properties of solid state materials in bulk, thin film and particulate forms. Papers dealing with synthesis, processing, characterization, structure, physical properties and computational aspects of nano-crystalline, crystalline, amorphous and glassy forms of ceramics, semiconductors, layered insertion compounds, low-dimensional compounds and systems, fast-ion conductors, polymers and dielectrics are viewed as suitable for publication. Articles focused on nano-structured aspects of these advanced solid-state materials will also be considered suitable.