Ultrafast microwave-assisted green synthesis of nitrogen-doped carbon dots as turn-off fluorescent nanosensors for determination of the anticancer nintedanib: Monitoring of environmental water samples

IF 4.1 Q1 CHEMISTRY, ANALYTICAL
Galal Magdy , Asmaa Kamal El-Deen , Aya Saad Radwan , Fathalla Belal , Heba Elmansi
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引用次数: 0

Abstract

This study unveils a swift and sustainable approach for the synthesis of nitrogen-doped carbon quantum dots (N-CQDs) from radish leaves and urea, conducted by microwave assistance within only 50 seconds, showcasing remarkable efficiency. Comprehensive characterization confirmed the distinctive optical properties of the N-CQDs, with a quantum yield of 19.76 %, highlighting their potential as fluorescent nanosensors. The N-CQDs exhibit turn-off fluorescence properties for sensing the anticancer drug nintedanib in different environmental water samples, including hospital discharge water, sewage water, tap water, and river water. The method exhibits excellent linearity within a concentration range of 1.0–20.0 µg/mL, with a correlation coefficient exceeding 0.999 and a low detection limit down to 0.14 μg/mL. The assay of nintedanib in various environmental water samples demonstrated the applicability and sensitivity of the N-CQDs as a detection platform. The ComplexMoGAPI, AGREE, and Green Certificate-modified Eco-Scale metrics demonstrated the method's exceptional eco-friendliness and sustainability. Additionally, the BAGI tool was employed to assess the method's economic viability, applicability, and practicality. All the tools demonstrated the sustainability and feasibility of the developed approach, as well as its appropriateness for the routine analysis of the examined drug. This work is considered the first spectrofluorimetric approach for the analysis of nintedanib. This innovative study also paves the way for eco-friendly nanosensors with diverse applications in environmental monitoring.

Abstract Image

超快微波辅助绿色合成掺氮碳点作为熄灭荧光纳米传感器,用于测定抗癌药物宁替达尼:监测环境水样
本研究揭示了一种快速和可持续的方法,可以在微波辅助下在50秒内从萝卜叶和尿素合成氮掺杂碳量子点(N-CQDs),显示出显着的效率。综合表征证实了N-CQDs独特的光学性质,量子产率为19.76%,突出了其作为荧光纳米传感器的潜力。N-CQDs具有关闭荧光特性,可在不同的环境水样中检测抗癌药物尼达尼布,包括医院排放水、污水、自来水和河水。方法在1.0 ~ 20.0µg/mL范围内线性良好,相关系数大于0.999,检出限低至0.14 μg/mL。通过对不同环境水样中尼达尼布的检测,验证了N-CQDs作为检测平台的适用性和灵敏度。ComplexMoGAPI、AGREE和Green Certificate-modified Eco-Scale指标证明了该方法卓越的生态友好性和可持续性。此外,利用BAGI工具评估该方法的经济可行性、适用性和实用性。所有工具都证明了所开发方法的可持续性和可行性,以及其对所检查药物的常规分析的适用性。这项工作被认为是第一个荧光光谱法分析尼达尼布。这项创新的研究也为生态友好型纳米传感器在环境监测中的各种应用铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Talanta Open
Talanta Open Chemistry-Analytical Chemistry
CiteScore
5.20
自引率
0.00%
发文量
86
审稿时长
49 days
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