Social networks, environmental, and individual factors associated with COVID-19 vaccination and booster uptake– The prospective PRIME cohort study

IF 2.7 Q3 IMMUNOLOGY

Vaccine: X Pub Date : 2025-02-25 DOI:10.1016/j.jvacx.2025.100626

Céline J.A. van Bilsen , Lisanne C.J. Steijvers , Stephanie Wagner , Demi M.E. Pagen , Senne M.C.E. Wijnen , Kevin Konings , Christian J.P.A. Hoebe , Annemarie Koster , Nicole H.T.M. Dukers-Muijrers

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Abstract

Background

Social networks (a person's social relationships) are important for health and in health behavior, including infection prevention behavior. This study aims to identify factors associated with coronavirus disease 2019 (COVID-19) vaccine and booster uptake, focusing on social networks and community participation factors, the physical environment, and individual level factors.

Methods

In the PRIME longitudinal cohort study, we used online questionnaires to collect baseline data at the end of 2021, including participants' COVID-19 vaccination status and various factors, i.e., structural and functional social network characteristics (interpersonal factors), societal (social and physical living environment) community (work and social participation), and individual (sociodemographics, health) factors. At follow-up (summer of 2022), we measured COVID-19 booster uptake. Associations between the factors and vaccine and booster uptake were analyzed using multivariable logistic regression analyses.

Results

At baseline (N = 9501), COVID-19 vaccine uptake was 94 %. In vaccinated participants at follow-up (N = 3620), booster uptake was 91 %. Community and societal factors associated with (booster) vaccine uptake included social participation, higher neighborhood livability and walkability scores, and a moderate level of urbanization. Interpersonal factors included a larger social network size, network diversity, network density, and not living alone. Associated individual factors included age ≥ 60 years, male sex, college/university education, being born in the Netherlands, having chronic conditions, being a never/former smoker, higher health literacy, and no loneliness.

Conclusion

The social and physical environment are key in COVID-19 vaccine and booster uptake. Health promotion and vaccination strategies should address the environmental context (community, societal and interpersonal factors) alongside individual-level factors to contribute to pandemic preparedness.

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与COVID-19疫苗接种和加强接种相关的社会网络、环境和个人因素——前瞻性PRIME队列研究

社会网络（一个人的社会关系）对健康和健康行为（包括感染预防行为）很重要。本研究旨在确定与2019冠状病毒病（COVID-19）疫苗和加强剂摄入相关的因素，重点关注社会网络和社区参与因素、物理环境因素和个人层面因素。方法在PRIME纵向队列研究中，我们使用在线问卷收集2021年底的基线数据，包括参与者的COVID-19疫苗接种状况以及各种因素，即结构和功能社会网络特征（人际因素）、社会（社会和物质生活环境）社区（工作和社会参与）和个人（社会人口、健康）因素。在随访期间（2022年夏季），我们测量了COVID-19增强剂的摄取情况。使用多变量logistic回归分析分析各因素与疫苗和增强剂摄取之间的关系。结果基线组（N = 9501） COVID-19疫苗接种率为94%。在随访期间接种疫苗的参与者中（N = 3620），加强接种率为91%。与（加强）疫苗接种相关的社区和社会因素包括社会参与，较高的社区宜居性和步行性评分，以及中等水平的城市化。人际关系因素包括更大的社会网络规模、网络多样性、网络密度和不独居。相关的个人因素包括年龄≥60岁、男性、大专/大学教育程度、在荷兰出生、患有慢性病、从未/曾经吸烟、较高的健康素养和不孤独。结论社会和自然环境是影响COVID-19疫苗和增强剂吸收的关键因素。健康促进和疫苗接种战略应处理环境背景（社区、社会和人际因素）以及个人层面的因素，以促进大流行病的防范。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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