Self-powered wearable electrochemical sensor based on composite conductive hydrogel medium for detection of lactate in human sweat

IF 10.7 1区生物学 Q1 BIOPHYSICS

Biosensors and Bioelectronics Pub Date : 2025-02-23 DOI:10.1016/j.bios.2025.117303

Jing Sun , Wanqing Dai , Qiang Guo , Yaru Gao , Jiayu Chen , Jian Lin Chen , Guozhu Mao , Hongyan Sun , Yung-Kang Peng

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引用次数: 0

Abstract

Sweat, a vital metabolic product in the human body, contains valuable biomarkers that reflect human conditions. Among these, lactate concentration serves as a significant indicator of human physiological states. In this study, we present an innovative self-powered wearable electrochemical sensor designed for real-time lactate detection in human sweat. This sensor utilizes a composite conductive hydrogel medium, showcasing its potential in monitoring and assessing human health. The sensor incorporates two key components: the lactate oxidase/reduced graphene oxide/carbon cloth electrode (LOx/rGO/CCE) as the anode and the bilirubin oxidase/reduced graphene oxide/carbon cloth electrode (BOx/rGO/CCE) as the cathode. These electrodes are integrated into a substrate comprising a conductive hydrogel composed of Poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and hydrophilic polyurethane (HPU). The sensor's performance was evaluated. The linear detection range spans from 10 nM to 50 mM, with an impressive detection limit of 4.38 nM, demonstrating its high sensitivity and selectivity towards lactate detection with long-term stability. Additionally, this sensor has been successfully applied to real-time monitor lactate concentration on athletes' skin by combining it with self-made equipment and smartphones. The test results demonstrate minimal error compared to the results obtained from high-performance liquid chromatography. This technology opens up a valuable tool for monitoring and assessing human physiological conditions and new possibilities for advancements in health management, sports monitoring, and medical diagnostics.

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来源期刊

Biosensors and Bioelectronics 工程技术-电化学

CiteScore

20.80

自引率

7.10%

发文量

1006

审稿时长

29 days

期刊介绍： Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.