A multi-degree-of-freedom model-based method for Young's modulus determination of soft tissue by resonance spectroscopy

IF 3.5 2区物理与天体物理 Q2 PHYSICS, APPLIED

Applied Physics Letters Pub Date : 2025-02-24 DOI:10.1063/5.0252527

Yujie Hu, Kecai Lu, Zhuangyu Li, Daming Zhou

引用次数: 0

Abstract

Elastic properties of soft tissues are important indicators for disease progression. Previous studies have utilized mechanical resonance spectroscopy to infer elastic properties of soft tissues by extracting their resonance frequencies. However, the method to accurately obtain the elastic modulus from the resonance frequencies remains inconclusive. In this study, we report a method based on a multi-degree-of-freedom (MDOF) model to determine the Young's modulus of soft tissue samples from the measured resonance spectroscopy. Resonance frequencies of agar tissue phantoms with different elastic properties were obtained, and Young's modulus was calculated using the MDOF-based method. The result was validated by mechanical compression tests and finite element method simulations. The results show that the multi-degree-of-freedom (MDOF)-based method is capable of determining Young's modulus of soft tissue samples with various elasticities and dimensions. This study provides an opportunity to accurately assess the elastic properties of small-sized soft tissue samples.

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来源期刊

Applied Physics Letters 物理-物理：应用

CiteScore

6.40

自引率

10.00%

发文量

1821

审稿时长

1.6 months

期刊介绍： Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.