Factors Impacting Live Birth Probability After In Vitro Fertilisation and Embryo Transfer in Women With Endometrial Cancer Following Conservative Therapy: A Retrospective Cohort Study

IF 4.7 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Bjog-An International Journal of Obstetrics and Gynaecology Pub Date : 2025-02-25 DOI:10.1111/1471-0528.18063

Ningning Pan, Hongyi Wei, Yang Wang, Rong Li, Caihong Ma

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引用次数: 0

Abstract

Objective

This study aimed to elucidate the factors influencing live birth outcomes following in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) after conservative therapy in women with early-stage endometrioid endometrial cancer (EEC).

Design

Single-centre retrospective cohort study.

Setting

Reproductive Center, Peking University Third Hospital.

Population

One hundred and seventeen women with Stage IA EEC who received conservative treatment and achieved complete remission.

Methods

Medical records from our database were retrospectively analysed.

Main Outcome Measures

Cumulative live births and endometrial cancer recurrence rates.

Results

The cumulative live birth rate of women who underwent controlled ovarian stimulation (COS) was significantly higher than in those who did not (43.7% vs. 20.0%; p = 0.021), whereas the endometrial cancer recurrence rate was similar (26.1% vs. 30%; p = 0.812). Of 87 patients who received COS cycles, 71 underwent embryo transfer, of which 38 resulted in live birth and 33 did not. There was a significant association between live births and both endometrial thickness (odds ratio [OR] 1.753, 95% confidence interval [CI] 1.174–2.616, p = 0.006) and the number of transferable embryos (OR 1.270, 95% CI 1.017–1.587, p = 0.035).

Conclusions

The chances of successful live births following IVF/ICSI-ET are encouraging for women diagnosed with EEC. Endometrial thickness and the number of transferable embryos are crucial factors associated with the success rate of live births in women with EEC undergoing IVF-ET.

查看原文本刊更多论文

影响子宫内膜癌患者保守治疗后体外受精和胚胎移植后活产概率的因素：一项回顾性队列研究

本研究旨在阐明早期子宫内膜样子宫内膜癌（EEC）妇女保守治疗后体外受精/胞浆内单精子注射（IVF/ICSI）后活产结局的影响因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bjog-An International Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

10.90

自引率

5.20%

发文量

345

审稿时长

3-6 weeks

期刊介绍： BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.