Association between Blood Trihalomethane Concentrations and the Risk of Dyslipidemia: Nationally Representative Cross-Sectional Study

IF 11.3 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

环境科学与技术 Pub Date : 2025-02-24 DOI:10.1021/acs.est.4c11066

Zi-Hao Xu, Xu-Lian Tang, Hong-Xuan Huang, Shu-Min Lai, Hong-Min Li, Dan-Qing Liao, Li-Ying Du, Zhi-Yuan Xiong, Ling Kuang, Bing-Yun Zhang, Hao-Jie Chen, Jia-Yin Han, Zhi-Hao Li

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Abstract

Experimental studies have indicated that exposure to disinfection byproducts (DBPs) may affect the lipid synthesis. However, epidemiological evidence is sparse. This study aimed to investigate the relationship between blood trihalomethane (THM) exposure and the risk of dyslipidemia from the National Health and Nutrition Examination Survey 2005–2018. We included adults (n = 16,159) whose blood concentrations of chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM) were quantified. Multivariable logistic regression revealed significantly elevated dyslipidemia risks in the highest group of TCM [adjusted odds ratios (ORs) = 1.30, 95% confidence intervals (CIs): 1.15–1.47], BDCM (1.23,1.07–1.42), TBM (1.35, 1.08–1.68), and total THMs (TTHMs; sum of all four THMs) (1.30, 1.14–1.48). In subgroup analysis, these associations were stronger among young/middle-aged individuals. In Weighted Quantile Sum regression and Quantile G-Computation analysis, combined THM exposure was positively associated with dyslipidemia risk. Our study provides new evidence of a positive association between blood THM concentrations and the risk of dyslipidemia, underscoring the need for further research to confirm these findings and explore the underlying mechanisms.

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血液三卤甲烷浓度与血脂异常风险之间的关系：全国代表性横断面研究

实验研究表明，暴露于消毒副产物（DBPs）可能会影响脂质合成。然而，流行病学证据很少。本研究旨在调查2005-2018年全国健康与营养调查中血液三卤甲烷（THM）暴露与血脂异常风险之间的关系。我们纳入成人（n = 16,159），他们的血液中氯仿（TCM）、溴二氯甲烷（BDCM）、二溴氯甲烷（DBCM）和溴仿（TBM）的浓度被量化。多变量logistic回归显示，服用中药最多的组血脂异常风险显著升高[调整优势比(or) = 1.30, 95%可信区间（ci）： 1.15-1.47], BDCM (1.23, 1.07-1.42)， TBM(1.35, 1.08-1.68)，总THMs (TTHMs；四种thm的总和)（1.30,1.14-1.48）。在亚组分析中，这些关联在青年/中年个体中更强。在加权分位数和回归和分位数g计算分析中，联合THM暴露与血脂异常风险呈正相关。我们的研究提供了血液THM浓度与血脂异常风险之间正相关的新证据，强调需要进一步的研究来证实这些发现并探索潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

环境科学与技术环境科学-工程：环境

CiteScore

17.50

自引率

9.60%

发文量

12359

审稿时长

2.8 months

期刊介绍： Environmental Science & Technology (ES&T) is a co-sponsored academic and technical magazine by the Hubei Provincial Environmental Protection Bureau and the Hubei Provincial Academy of Environmental Sciences. Environmental Science & Technology (ES&T) holds the status of Chinese core journals, scientific papers source journals of China, Chinese Science Citation Database source journals, and Chinese Academic Journal Comprehensive Evaluation Database source journals. This publication focuses on the academic field of environmental protection, featuring articles related to environmental protection and technical advancements.