Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-22 DOI:10.1016/j.pdpdt.2025.104530

Irfan Botan Gunes , Eda Demir Onal

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Abstract

Purpose

To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A).

Methods

Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy subjects in the control group (CG) were included in the study. Macular superficial retinal blood flow (SRBF), peripapillary RNFL thickness and optic nerve head cup to disk ratio (C/D) were measured and recorded by OCT angiography and compared between the patient and control groups. Correlation analysis between disease duration and SRBF and RNFL thickness was also performed.

Results

Mean SRBF was 37.23 ± 2.11 in the SCH group and 38.45±1.20 in the control group. Mean SRBF was significantly lower in the SCH group (p=0.003). Mean Peripapillary RNFL thickness was 98.18±7.77 in the SCH group and 100.07 ± 7.71 in control group. Peripapillary RNFL thickness was not significantly different between groups (p=0.290). There was no significant difference in mean C/D between the groups (p=0.708). Correlation analysis showed a moderate negative correlation between duration of disease diagnosis and SRBF in the SCH group (p<0.001, r=-0.564). There was also a weak to moderate negative correlation between disease duration and RNFL thickness in SCH group (p=0.002, r=-0.489).

Conclusions

A reduction in SRBF was observed in patients with subclinical hypothyroidism. Additionally, a negative correlation was identified between disease duration and RNFL thickness. Patients with subclinical hypothyroidism should be monitored for potential retinal vascular disease and the development of normotensive glaucoma.

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亚临床甲状腺功能减退症对视网膜血流影响的评价。OCT血管造影研究。

目的：应用光学相干断层扫描血管造影（OCT-A）评价未经治疗的亚临床甲状腺功能减退患者的视网膜血流量和视网膜神经纤维层（RNFL）厚度。方法：选取亚临床甲状腺功能减退组（SCHG） 44例患者的44只眼和对照组（CG） 42例健康者的42只眼作为研究对象。通过OCT血管造影测量并记录黄斑视网膜浅血流量（SRBF）、乳头周围RNFL厚度、视神经头杯盘比（C/D），并与对照组进行比较。分析病程与SRBF、RNFL厚度的相关性。结果：SCH组平均SRBF为37.23±2.11，对照组平均SRBF为38.45±1.20。SCH组的平均SRBF显著低于对照组（p=0.003）。SCH组平均乳头周围RNFL厚度为98.18±7.77，对照组为100.07±7.71。两组间乳头周围RNFL厚度差异无统计学意义（p=0.290）。两组间平均C/D比较差异无统计学意义（p=0.708）。相关分析显示，SCH组疾病诊断时间与SRBF之间存在中度负相关(结论：亚临床甲状腺功能减退患者SRBF降低。此外，疾病持续时间与RNFL厚度呈负相关。亚临床甲状腺功能减退患者应监测潜在的视网膜血管疾病和发展为常压青光眼。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.