Alterations in cerebral artery flow velocity acceleration pattern correlate with cognitive impairment in diabetes mellitus.

IF 1.4 4区 心理学 Q4 CLINICAL NEUROLOGY
Ahmet Tas, Muhammed Ikbal Bayhan, Mehlika Yildiz, Yaren Alan, Zeynep Atay, Fatih Sezer, Cagla Kitapli, Ilke Kara Tas, Sabahattin Umman, Murat Sezer
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引用次数: 0

Abstract

Introduction: Flow velocity acceleration pattern is related to shear stress, pressure changes, cardiovascular risk factors, diabetes mellitus, hypertension, endothelial dysfunction and arterial stiffness. Considering the hemodynamic alterations in cognitive impairment, perturbations in cerebral artery flow acceleration pattern may correlate with cognitive impairment, which could enhance our understanding of how cardiovascular risk factors drive cognitive decline from a mechanistic point of view.

Method: The first derivative of middle cerebral artery flow velocity waveforms obtained via transcranial Doppler were computed to visualize acceleration/deceleration waves (a,b,c,d,e) in ensemble-averaged signals. Vascular Aging Index was calculated per its definition (VAI:(b-c-d-e)/a). Relationship between multiple cognitive domains and VAI was evaluated with standard statistical tests.

Results: VAI was significantly correlated with HVLT total recall (Hopkins Verbal Learning Test-revised) (r: -0.310 p: 0.046, n: 42), delayed recall (r: -0.396 p: 0.009), % Retention (r: -0.305 p: 0.050) and components of RCFT(Rey-Osterrieth Complex Figure Test), namely raw copy score (r: -0.524 p < 0.001), immediate recall (r: -0.323 p: 0.037). Controlling for age, body mass index, gray matter volume and diabetes duration yielded stronger correlations but lower group numbers due to missing data. Correlation coefficients for VAI with HVLT delayed recall and % Retention were -0.439 (p: 0.012) and -0.444(p: 0.011 n: 36) respectively. Likewise the adjusted correlations of VAI with RCFT components were improved (Raw Copy r: -0.557 p < 0.001, Immediate Recall r: -0.440 p: 0.012, Delayed Recall (r: -0.358 p: 0.044).

Conclusion: In patients with diabetes, cerebral artery flow velocity acceleration pattern correlates with cognitive performance in visuo-constructional and verbal cognitive domains. Computational fluid dynamics may aid developing a better mechanistic understanding of arterial hemodynamics-cortical function coupling.

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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
CiteScore
4.50
自引率
11.80%
发文量
134
期刊介绍: pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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