Causes of death in patients with malignant adrenal tumours: a population-based analysis.

IF 5.4 2区 医学 Q1 Medicine
Yang Zheng, Song Ren, Zeyi Yan, Ting Hu, Yunlin Feng, Dong Wang, Shida Fan, Shangqing Ren
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引用次数: 0

Abstract

Objective: This study aimed to characterize the causes of death and compute the risk of mortality due to each cause among patients with malignant adrenal tumours.

Methods: Data from malignant adrenal tumour patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2020). With reference data from the general population, the standardized mortality ratio (SMR) was calculated to assess all causes of death for malignant adrenal tumour patients.

Results: A total of 1651 patients who died from primary malignant adrenal neoplasms were included; 854 cases of adrenocortical carcinoma (ACC)-related death, 118 cases of pheochromocytoma (PCC)-related death and 333 cases of neuroblastoma (NB)-related death were identified for further analysis. Approximately 56.78%~87.69% of patients died from primary malignant adrenal tumours, 7.21%~13.56% died from secondary malignant neoplasms (SMNs), and 5.11%~29.66% died from noncancer diseases. The main causes of death associated with SMNs included lung and bronchial cancer and soft tissue cancers, including heart, kidney and renal pelvis cancers; the noncancer causes of death included mainly heart disease, septicemia, and cerebrovascular disease. Compared with chemotherapy-naïve patients, chemotherapy-treated patients had higher SMRs of SMNs, including cancers of the colon (excluding the rectum), lung, bronchus, bones and joints; soft tissues, including the heart, kidney and renal pelvis; the brain and peripheral nervous system; and leukaemia, as well as nontumor diseases, including heart disease, septicemia, and cerebrovascular disease. Patients with NB were more likely to die from SMNs, including soft-tissue malignancies of the heart, bones and joints; brain; peripheral nervous system; the female genital system, including the ovary; leukaemia, including lymphocytic leukaemia; myeloid and monocytic leukaemia; and lymphoma, including non-Hodgkin lymphoma.

Conclusion: In addition to primary cancer, SMNs and nontumor diseases were important causes of death in patients with malignant adrenal tumours. Neuroblastoma patients and chemotherapy- treated patients are more likely to die from SMNs and should monitored closely.

恶性肾上腺肿瘤患者的死亡原因:基于人群的分析
目的:本研究旨在描述恶性肾上腺肿瘤患者的死亡原因,并计算每种原因导致的死亡风险。方法:从监测、流行病学和最终结果(SEER)数据库(2004-2020)中收集恶性肾上腺肿瘤患者的数据。结合普通人群的参考数据,计算标准化死亡率(SMR)以评估恶性肾上腺肿瘤患者的所有死亡原因。结果:共纳入1651例原发性肾上腺恶性肿瘤死亡患者;854例肾上腺皮质癌(ACC)相关死亡,118例嗜铬细胞瘤(PCC)相关死亡,333例神经母细胞瘤(NB)相关死亡。原发性肾上腺恶性肿瘤死亡占56.78%~87.69%,继发性恶性肿瘤(SMNs)死亡占7.21%~13.56%,非肿瘤死亡占5.11%~29.66%。与SMNs相关的主要死亡原因包括肺癌和支气管癌以及软组织癌,包括心脏、肾脏和肾盂癌;非癌症死亡原因主要包括心脏病、败血症和脑血管疾病。与chemotherapy-naïve患者相比,化疗患者smn的smr更高,包括结肠癌(不包括直肠)、肺癌、支气管癌、骨骼和关节癌;软组织,包括心脏、肾脏和肾盂;大脑和周围神经系统;白血病,以及非肿瘤疾病,包括心脏病、败血症和脑血管疾病。NB患者更有可能死于SMNs,包括心脏、骨骼和关节的软组织恶性肿瘤;大脑;周围神经系统;女性生殖系统,包括卵巢;白血病,包括淋巴细胞白血病;髓系和单核细胞白血病;和淋巴瘤,包括非霍奇金淋巴瘤。结论:除原发肿瘤外,SMNs和非肿瘤疾病是恶性肾上腺肿瘤患者死亡的重要原因。神经母细胞瘤患者和化疗患者更有可能死于smn,应密切监测。
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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
8.10
自引率
7.40%
发文量
242
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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