Effect of Exercise and Nutrition Intervention for Older Adults with Impaired Physical Function with Preserved Muscle Mass (Functional Sarcopenia): A Randomized Controlled Trial.
Sunghwan Ji, Ji Yeon Baek, Jin Go, Chang Ki Lee, Sang Soo Yu, Eunju Lee, Hee-Won Jung, Il-Young Jang
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引用次数: 0
Abstract
Background: Functional sarcopenia is characterized by decreased physical performance and grip strength despite preserved muscle mass. The effectiveness of a program combining exercise and nutritional support-known interventions for individuals with low muscle mass-was evaluated for its impact on older adults with functional sarcopenia.
Methods: An unblinded, parallel-group randomized controlled trial was conducted in a public medical center in a rural Korean community. Eligible older adults with functional sarcopenia were randomized into either the intervention group, receiving a 12-week program of group exercises and nutritional support, or the control group, receiving education on lifestyle management. Outcomes measured included changes in gait speed, grip strength, physical performance, and quality of life indices.
Results: The study enrolled 42 participants, with 21 allocated to each group. Compared with the control group, the intervention group showed significant improvements in the primary outcome of gait speed (mean change (m/s) 0.24 vs 0.00, p<0.001) and secondary outcomes, such as Short Physical Performance Battery scores, grip strength, and quality of life. No significant adverse events were reported.
Conclusion: The 12-week exercise and nutritional intervention significantly enhanced physical performance, grip strength, and quality of life among community-dwelling older adults with functional sarcopenia. This suggests that strategies commonly recommended for sarcopenia, including exercise and nutritional support, are also beneficial for individuals with functional sarcopenia, indicating the potential for broader application of such interventions.
背景：功能性肌肉减少症的特征是尽管保留了肌肉量，但身体表现和握力下降。一项将锻炼和营养支持相结合的项目的有效性——已知的针对低肌肉量个体的干预措施——被评估了其对患有功能性肌肉减少症的老年人的影响。方法：在韩国农村社区的公共医疗中心进行了一项非盲、平行组随机对照试验。符合条件的功能性肌肉减少症老年人被随机分为干预组和对照组，干预组接受为期12周的团体锻炼和营养支持，对照组接受生活方式管理教育。测量的结果包括步态速度、握力、身体表现和生活质量指数的变化。结果：该研究招募了42名参与者，每组21人。与对照组相比，干预组在步态速度的主要指标（平均变化（m/s） 0.24 vs 0.00, p）上有显著改善。结论：12周的运动和营养干预显著提高了社区老年功能性肌少症患者的身体表现、握力和生活质量。这表明，通常推荐的治疗肌肉减少症的策略，包括运动和营养支持，也对功能性肌肉减少症患者有益，表明此类干预措施有更广泛应用的潜力。
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
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