Persistent Corneal Epithelial Defect Following Pars Plana Vitrectomy: A Narrative Review.

IF 1.9 4区医学 Q2 OPHTHALMOLOGY

Seminars in Ophthalmology Pub Date : 2025-02-24 DOI:10.1080/08820538.2025.2470253

Makan Ziafati, Reza Mirshahi, Maria Vittoria Cicinelli, Rezvaneh Nazari

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引用次数: 0

Abstract

Purpose: Persistent corneal epithelial defects (PCEDs) following pars plana vitrectomy (PPV) represent a significant clinical challenge, potentially leading to corneal scarring, vision loss, and other severe complications. This review aims to summarize the prevalence, associated risk factors, and management strategies for PCEDs in the context of PPV, providing evidence-based guidance for clinicians.

Methods: A comprehensive systematic review was conducted using PubMed and Embase databases, identifying English-language studies addressing PCEDs after PPV.

Results: The prevalence of PCEDs post-PPV varied widely, from 0% to 78.37%, influenced by intrinsic factors such as diabetes mellitus, which impairs corneal nerve function and healing, and extrinsic factors like intraoperative tamponade with C3F8. Management strategies ranged from conservative options like bandage contact lenses to advanced treatments like topical insulin.

Conclusion: PCEDs after PPV are multifactorial and demand individualized management. Advanced therapies, particularly serum-based treatments, and topical insulin, show promising outcomes. Further prospective research is warranted to refine these treatments.

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玻璃体部分切除术后持续性角膜上皮缺损：叙述回顾。

目的：玻璃体部分切除术（PPV）后的持续性角膜上皮缺损（PCEDs）是一个重大的临床挑战，可能导致角膜瘢痕、视力丧失和其他严重并发症。本综述旨在总结PPV背景下pced的患病率、相关危险因素和管理策略，为临床医生提供循证指导。方法：使用PubMed和Embase数据库进行全面的系统评价，确定针对PPV后pced的英语研究。结果：ppv术后PCEDs的患病率差异较大，从0% ~ 78.37%不等，受糖尿病等影响角膜神经功能及愈合的内在因素和术中C3F8填塞等外在因素的影响。治疗策略包括从绷带隐形眼镜等保守选择到局部胰岛素等高级治疗。结论：PPV术后pced是多因素的，需要个体化治疗。先进的治疗方法，特别是基于血清的治疗和局部胰岛素，显示出有希望的结果。需要进一步的前瞻性研究来完善这些治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.