Four meroterpenoids from the leaves of Psidium guajava L. and their cytotoxicity activities.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-23 DOI:10.1080/14786419.2025.2469323

Li-Jun Qiao, Cai-Zhi Li, Aijia Ji, Qian Feng

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Abstract

In this study, two previously undescribed meroterpenoids, Psidiguajadiol G (1) and H (2), together with 2 known analogues, were isolated from leaves of Psidium guajava L. Their structures were confirmed by comparative analysis of spectroscopic analyses, calculated and measured electronic circular dichroism (ECD). Further in vitro experiments were used to detect cytotoxicity, anti-proliferation and apoptosis/necrosis effects of compounds in variously cancer cells. Our results confirmed that compound 1 and 2 exhibited broad spectrum cytotoxicity effects in cancer cells. The cytotoxicity effects of compound 1 were MCF-7 > OVCAR-3 > SKOV3 ≈ MDA-MB-231 > HCT116 > H1299 > 22Rv1. Compound 1 and 2 exerted significantly killing effects in women highly prevalent breast and ovarian cancer by inhibiting cell proliferation, promoting necrotic cell death and apoptotic programmed death. Compounds 3 and 4 showed slightly lower cytotoxic effects on tumour cells, and also exhibited different killing effects between female cancers and male cancer.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.