Evaluation of polyphenolic profile, antioxidant, anti-cholinesterase, and anti-alpha-amylase activities of Pistacia lentiscus L. leaves.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-24 DOI:10.1080/14786419.2025.2471836

Samira Moussaoui, El Hassen Mokrani, Zahia Kabouche, Assia Guendouze, Amina Laribi, Nesrine Bradai, Chawki Bensouici, Mustafa Abdullah Yilmaz, Oguz Cakir, Abbas Tarhan

{"title":"Evaluation of polyphenolic profile, antioxidant, anti-cholinesterase, and anti-alpha-amylase activities of Pistacia lentiscus L. leaves.","authors":"Samira Moussaoui, El Hassen Mokrani, Zahia Kabouche, Assia Guendouze, Amina Laribi, Nesrine Bradai, Chawki Bensouici, Mustafa Abdullah Yilmaz, Oguz Cakir, Abbas Tarhan","doi":"10.1080/14786419.2025.2471836","DOIUrl":null,"url":null,"abstract":"The phytochemical profile of the hydro-methanolic extract from Pistacia lentiscus L. leaves (MEPLL) was analysed using the LC-ESI-MS/MS method, which identified 17 compounds. The major compounds identified were quinic acid (234.25 mg/g extract), tannic acid (45.92 mg/g extract), quercitrin (2.99 mg/g extract), protocatechuic acid (1.96 mg/g extract), and gallic acid (1.34 mg/g extract). MEPLL exhibited the most potent antioxidant activity, with IC50 values of 4.79 ± 0.31 µg/mL for DPPH, 2.80 ± 0.02 µg/mL for ABTS, and an A0.5 value of 3.80 ± 0.64 µg/mL for the phenanthroline assay. Additionally, MEPLL exhibited significant inhibitory effects against acetylcholinesterase (AChE) (IC50 = 5.76 ± 0.97 µg/mL), butyrylcholinesterase (BChE) (IC50 = 28.94 ± 1.48 µg/mL), and α-amylase (IC50 = 8.9 ± 0.14 µg/mL), outperforming the positive controls. Molecular docking studies further supported these in vitro results.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2471836","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

The phytochemical profile of the hydro-methanolic extract from Pistacia lentiscus L. leaves (MEPLL) was analysed using the LC-ESI-MS/MS method, which identified 17 compounds. The major compounds identified were quinic acid (234.25 mg/g extract), tannic acid (45.92 mg/g extract), quercitrin (2.99 mg/g extract), protocatechuic acid (1.96 mg/g extract), and gallic acid (1.34 mg/g extract). MEPLL exhibited the most potent antioxidant activity, with IC₅₀ values of 4.79 ± 0.31 µg/mL for DPPH, 2.80 ± 0.02 µg/mL for ABTS, and an A_0.5 value of 3.80 ± 0.64 µg/mL for the phenanthroline assay. Additionally, MEPLL exhibited significant inhibitory effects against acetylcholinesterase (AChE) (IC₅₀ = 5.76 ± 0.97 µg/mL), butyrylcholinesterase (BChE) (IC₅₀ = 28.94 ± 1.48 µg/mL), and α-amylase (IC₅₀ = 8.9 ± 0.14 µg/mL), outperforming the positive controls. Molecular docking studies further supported these in vitro results.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.