Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions.

IF 5.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Enzyme Inhibition and Medicinal Chemistry Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI:10.1080/14756366.2025.2468853

Xingyi Lv, Chenyi Yang, Xianying Li, Yun Liu, Yu Yang, Tongyan Jin, Zhijian Chen, Jinjing Jia, Min Wang, Li Li

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引用次数: 0

Abstract

Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention and regeneration strategies. Ferroptosis, a distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due to its potential role in cancer, ageing, and neuronal degeneration, especially hearing loss. The emerging role of ferroptosis as a crucial mediator in SNHL suggests that it may offer a novel therapeutic target for otoprotection. This review aims to summarise the intricate connection between ferroptosis and SNHL, offering a fresh perspective for exploring targeted therapeutic strategies that could potentially mitigate cochlear cells damage and enhance the quality of life for individuals with hearing impairments.

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下垂铁与听力损失：从分子机制到治疗干预。

听力损失严重影响社会参与、心理健康、认知和大脑发育，其中感音神经性听力损失（SNHL）是一个主要问题。SNHL与耳毒性药物、衰老和噪音暴露有关，提出了重大的治疗挑战，强调了有效预防和再生策略的必要性。铁下垂是一种独特的细胞死亡形式，以铁依赖性脂质过氧化为特征，由于其在癌症、衰老和神经元变性，特别是听力损失中的潜在作用而引起了人们的兴趣。铁下垂作为SNHL的重要介质的新作用表明它可能为耳保护提供新的治疗靶点。本综述旨在总结铁上垂症与SNHL之间的复杂联系，为探索有针对性的治疗策略提供新的视角，这些治疗策略可能会减轻耳蜗细胞损伤，提高听力障碍患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Enzyme Inhibition and Medicinal Chemistry 医学-生化与分子生物学

CiteScore

10.30

自引率

10.70%

发文量

195

审稿时长

4-8 weeks

期刊介绍： Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research. The journal’s focus includes current developments in: Enzymology; Cell biology; Chemical biology; Microbiology; Physiology; Pharmacology leading to drug design; Molecular recognition processes; Distribution and metabolism of biologically active compounds.