Optimization of ultrasonic-assisted extraction of flavonoids from Ficus carica leaves and its chemical composition, antioxidant and UVB-protective properties.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-02-24 DOI:10.1080/10286020.2025.2467324

Wei Liu, Meriem Fizir, Jia-Wei Shi, Lu-Xing Zhang, Wei Lin, Zhi-Liang Chen, Jing Ding

引用次数: 0

Abstract

This study explored the protective effects of Ficus carica leaves (FCLs) against UVB radiation. Using response surface methodology (RSM), optimal extraction conditions for flavonoids were established, yielding 35.28 mg/g. HPLC-MS/MS analysis identified the components and various tests assessed their antioxidant and UVB protective capabilities. A sunscreen formulation with 0.10 wt% FCLs achieved an SPF of 25.6, surpassing commercial products (SPF 25). Additionally, FCLs extracts reduced E. coli mortality and protected zebrafish tail fin from damage after UVB exposure. These findings suggest FCLs are promising for sunscreen and antioxidant applications and may benefit psoriasis and vitiligo treatment.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.