Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease.

IF 2.6 Q2 CLINICAL NEUROLOGY

Journal of Central Nervous System Disease Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI:10.1177/11795735251322450

Yali Tang, Yizhu Zhang, Chen Chen, Ying Cao, Qiaona Wang, Chuanfeng Tang

{"title":"Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease.","authors":"Yali Tang, Yizhu Zhang, Chen Chen, Ying Cao, Qiaona Wang, Chuanfeng Tang","doi":"10.1177/11795735251322450","DOIUrl":null,"url":null,"abstract":"<p><p>Under normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut microbiota homeostasis has attracted significant research interest, specifically in its impact on neurological and psychiatric disorders. Recent studies have highlighted the important role of the gut- brain axis in conditions including Alzheimer's Disease (AD), Parkinson's Disease (PD), and depression. This review aims to elucidate the regulatory mechanisms by which gut microbiota affect the progression of CNS disorders via the gut-brain axis. Additionally, we discuss the current research landscape, identify gaps, and propose future directions for microbial interventions against these diseases. Finally, we provide a theoretical reference for clinical treatment strategies and drug development for AD, PD, and depression.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":"17 ","pages":"11795735251322450"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846125/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Central Nervous System Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11795735251322450","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Under normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut microbiota homeostasis has attracted significant research interest, specifically in its impact on neurological and psychiatric disorders. Recent studies have highlighted the important role of the gut- brain axis in conditions including Alzheimer's Disease (AD), Parkinson's Disease (PD), and depression. This review aims to elucidate the regulatory mechanisms by which gut microbiota affect the progression of CNS disorders via the gut-brain axis. Additionally, we discuss the current research landscape, identify gaps, and propose future directions for microbial interventions against these diseases. Finally, we provide a theoretical reference for clinical treatment strategies and drug development for AD, PD, and depression.

查看原文本刊更多论文

在正常生理条件下，肠道微生物群与宿主共存。它们在维持肠道屏障完整性、吸收和新陈代谢，以及促进中枢神经系统（CNS）发育和情绪调节方面发挥着关键作用。肠道微生物群平衡失调引起了大量研究兴趣，特别是其对神经和精神疾病的影响。最近的研究强调了肠道-大脑轴在阿尔茨海默病（AD）、帕金森病（PD）和抑郁症等疾病中的重要作用。本综述旨在阐明肠道微生物群通过肠脑轴影响中枢神经系统疾病进展的调节机制。此外，我们还讨论了当前的研究状况，找出了差距，并提出了微生物干预这些疾病的未来方向。最后，我们为针对注意力缺失症、帕金森病和抑郁症的临床治疗策略和药物开发提供了理论参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊