Alexios Giannakodimos, Evangelos Oikonomou, Panteleimon Pantelidis, Panagiotis Theofilis, Niki Katsiki, Athina Goliopoulou, Georgios E Zakynthinos, Emmanouil Korakas, Vasiliki Kalogera, Maciej Banach, Vaia Lampadiari, Eva Kassi, Ignatios Ikonomidis, Gerasimos Siasos
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引用次数: 0
Abstract
Introduction: The purpose of this systematic review and meta-analysis is to investigate the association of metabolic dysfunction-associated steatotic liver disease (MASLD) with arterial stiffness and enlighten on potential cardiometabolic co-factors.
Methods: A literature search in PubMed/Medline, Embase, Scopus, and Web of Science databases was conducted. All the observational studies comparing arterial stiffness indices between adults with Non-alcoholic Fatty Liver Disease (NAFLD), Metabolic Dysfunction Associated-Fatty Liver Disease (MAFLD), or MASLD and apparently healthy individuals with normal liver function were included. Pulse wave velocity (PWV) and augmentation index (AIx) were mainly used as arterial stiffness indices.
Results: Fourty one unique studies were included in the systematic review, with 27 deemed eligible for meta-analysis. Patients with MASLD had increased carotid-femoral PWV (14 studies, Mean difference (MD): 0.96 m/s, 95% confidence interval (CI) 0.65-1.27, p < 0.001) compared with healthy individuals. This finding was independent from body mass index, triglycerides, high-density lipoprotein, systolic blood pressure, and fasting plasma glucose. Moreover, patients with MASLD had higher brachial-ankle PWV (13 studies, MD: 78.14 cm/s, 95% CI 60.37-95.90, p < 0.001) and AIx (7 studies, MD: 3.85%, 95% CI 0.87-6.82, p = 0.0195) compared with controls.
Conclusions: MASLD is correlated with increased arterial stiffness. This relation is unaffected by common cardiometabolic risk factors.
简介：本系统综述和荟萃分析的目的是研究代谢功能障碍相关脂肪变性肝病（MASLD）与动脉僵硬的关系，并揭示潜在的心脏代谢辅助因素。方法：在PubMed/Medline、Embase、Scopus、Web of Science数据库中进行文献检索。所有比较非酒精性脂肪性肝病（NAFLD）、代谢功能障碍相关脂肪性肝病（MAFLD）或MASLD与肝功能正常的明显健康个体之间动脉僵硬指数的观察性研究都被纳入。动脉刚度指标主要采用脉搏波速度（PWV）和增强指数（AIx）。结果：41项独特的研究被纳入系统评价，其中27项被认为有资格进行meta分析。与对照组相比，MASLD患者颈动脉-股骨PWV增加（14项研究，平均差异（MD）： 0.96 m/s， 95%可信区间（CI） 0.65-1.27, p p p = 0.0195）。结论：MASLD与动脉硬化增加相关。这种关系不受常见的心脏代谢危险因素的影响。注册：普洛斯彼罗（ID: CRD42023468258）。
期刊介绍：
The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.
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