Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease.

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Veronica Ghiglieri, Paolo Calabresi
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引用次数: 0

Abstract

Since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-HT) and dopamine (DA) transmission is essential for regulating synaptic plasticity in the striatum (STR), prefrontal cortex (PFC), and hippocampus (HPC).. Experimental models have provided strong evidence of a synergistic action of DA and 5-HT convergent release in PFC, HPC, and STR to modulate motor control, learning, and memory processes. In this review, we will discuss the mechanisms underlying the actions of agonists and antagonists of 5-HT and DA receptors on striatal synaptic plasticity in physiological conditions and Parkinson's disease (PD), a movement disorder in which an imbalance of these two neurotransmitter systems has been hypothesized. This review will also discuss the interactions between 5-HT and DA in PFC and HPC, with particular regard to the influence of this crosstalk on synaptic plasticity and learning. Finally, we will provide an overview of how stimulation or inhibition of DA and 5- HT receptors affects these neurotransmitter expression levels in the three brain regions of interest.

帕金森病中5 -羟色胺和多巴胺系统的突触相互作用。
由于5-羟色胺和多巴胺传入神经都密集支配中枢神经系统的许多部分,因此5-羟色胺(5-HT)和多巴胺(DA)传递之间的完整串扰对于调节纹状体(STR)、前额叶皮质(PFC)和海马(HPC)的突触可塑性至关重要。实验模型提供了强有力的证据,表明DA和5-HT在PFC、HPC和STR中的收敛释放协同作用,调节运动控制、学习和记忆过程。在这篇综述中,我们将讨论5-羟色胺受体和DA受体的激动剂和拮抗剂在生理条件和帕金森病(PD)中纹状体突触可塑性的作用机制,帕金森病是一种运动障碍,其中这两种神经递质系统的失衡被假设。本文还将讨论5-羟色胺和DA在PFC和HPC中的相互作用,特别是这种串音对突触可塑性和学习的影响。最后,我们将概述DA和5- HT受体的刺激或抑制如何影响这些神经递质在三个感兴趣的大脑区域的表达水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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