Blood Flow Velocities as Determined by Real-Time Phase-Contrast MRI in Patients With Carotid Artery Stenosis

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-02-24 DOI:10.1111/jon.70016

Deborah Bochert, Sabine Hofer, Peter Dechent, Jens Frahm, Mathias Bähr, Jan Liman, Ilko Maier

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Abstract

Background and Purpose

Real-time phase-contrast (RT-PC) flow MRI can be used to determine quantitative flow parameters throughout the vessel lumen of extracranial, brain-supplying arteries. Its potential value in the diagnostic workup of patients with carotid artery stenosis has not been evaluated.

Methods

RT-PC flow MRI was performed in 10 patients with carotid stenosis in comparison to conventional neurovascular ultrasound (nvUS). Peak systolic velocity, end-diastolic velocity, mean flow velocity, and flow volumes have been evaluated by RT-PC flow MRI. Measurements have been performed at standardized sites along the common, internal, and external carotid arteries on both sides and at the maximum of the carotid stenosis.

Results

Blood flow velocities were significantly lower with RT-PC flow MRI compared to nvUS and not consistently correlated between both methods. Within the maximum of the carotid stenosis, RT-PC flow MRI showed implausible flow velocity reductions compared to nvUS. In contrast, the flow volumes determined by RT-PC flow MRI—with exception of the stenosis maximum—were comparable with nvUS and significantly correlated in the prestenotic common carotid artery.

Conclusion

RT-PC flow MRI does not appear to be suitable for quantifying blood flow velocities and volumes in the patients with carotid stenosis compared to nvUS. Apart from the lower temporal resolution of RT-PC MRI, the lack of correlation of blood flow velocities might be ascribed to the prevalence of nonlaminar flow within and behind the stenosis, which violates a general prerequisite for valid flow velocity measurements by PC MRI.

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颈动脉狭窄患者的实时相衬MRI血流速度测定

背景与目的实时相衬（RT-PC）血流MRI可用于测定颅内外供脑动脉血管腔内的定量血流参数。其在颈动脉狭窄患者诊断中的潜在价值尚未得到评价。方法对10例颈动脉狭窄患者行RT-PC血流MRI检查，并与常规神经血管超声（nvUS）进行比较。采用RT-PC血流MRI评估收缩期峰值速度、舒张末期速度、平均血流速度和血流体积。在沿颈总动脉、颈内动脉和颈外动脉两侧以及颈动脉狭窄最严重处的标准化位置进行测量。结果与nvUS相比，RT-PC血流MRI的血流速度明显降低，两种方法之间的相关性不一致。在颈动脉狭窄的最大范围内，与nvUS相比，RT-PC血流MRI显示难以置信的血流速度降低。相比之下，RT-PC血流mri（除最大狭窄外）测定的血流容量与nvUS相当，并且在狭窄的颈总动脉中显著相关。结论与nvUS相比，RT-PC血流MRI似乎不适合量化颈动脉狭窄患者的血流速度和血流体积。除了RT-PC MRI的时间分辨率较低外，血流速度缺乏相关性可能归因于狭窄内和狭窄后普遍存在非层流，这违反了PC MRI有效测量血流速度的一般先决条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!