Ukrainian guideline for the prevention and treatment of glucocorticoid-induced osteoporosis

IF 3.1 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
N. V. Grygorieva, V. M. Kovalenko, M. O. Кorzh, M. D. Tronko, I. Yu. Golovach, N. V. Dedukh, D. G. Rekalov, S. S. Strafun, S. I. Smiyan, O. A. Golubovska, Ya.O. Dziublyk, N. V. Kharchenko, G. O. Protsenko, O. O. Garmish, V. L. Orlenko, F. V. Klymovytskyy, A. S. Musiienko, T. A. Karasevska, Ukrainian Association of Osteoporosis
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引用次数: 0

Abstract

Introduction

Glucocorticoid-induced osteoporosis (GIOP) is a bone metabolic disorder caused by glucocorticoid (GC) use. It is one of the leading causes of secondary osteoporosis, increasing the risk of low-energy fractures, disability, and mortality. Although limited studies on GIOP epidemiology and treatment have been conducted in Ukraine, there were no national guidelines for its management. The aim was to create national guideline for the GIOP diagnosis, prevention, and treatment based on a comprehensive review of modern literature to enhance awareness within Ukraine’s medical community, improve disease management, and reduce its socio-economic impact.

Materials and methods

An Expert Group comprising 18 leading Ukrainian scientists from various fields was created for guideline development. A review of modern literature on GIOP epidemiology, risk factors, diagnosis, prevention, treatment, and monitoring was conducted. Evidence synthesis followed the GRADE methodology, and the quality of recommendations was critically evaluated using the AGREE II tool.

Results

The guideline comprises 12 statements covering GIOP screening, diagnosis, prevention, and treatment. We highlight the need to raise awareness among healthcare providers and patients about the potential effects of GC therapy. Also, we outline approaches to clinical assessment of osteoporotic fracture risk in GC users and detail diagnostic and therapeutic methods currently available in Ukraine for managing GIOP.

Conclusion

The first Ukrainian national GIOP guideline is critical for healthcare providers across specialities. Endorsed by the Board of the Ukrainian Association of Osteoporosis, it is recommended for use in routine clinical practice to enhance patient outcomes and mitigate the disease’s impact.

Abstract Image

乌克兰糖皮质激素所致骨质疏松症的预防和治疗指南
糖皮质激素诱导的骨质疏松症(GIOP)是一种由糖皮质激素(GC)使用引起的骨代谢紊乱。它是继发性骨质疏松症的主要原因之一,增加了低能量骨折、残疾和死亡的风险。虽然乌克兰对GIOP的流行病学和治疗进行了有限的研究,但没有关于其管理的国家指南。目的是在对现代文献进行全面审查的基础上,为GIOP的诊断、预防和治疗制定国家指南,以提高乌克兰医学界的认识,改善疾病管理,并减少其社会经济影响。材料和方法成立了一个由来自不同领域的18名乌克兰顶尖科学家组成的专家组,以制定指导方针。本文对GIOP流行病学、危险因素、诊断、预防、治疗和监测方面的现代文献进行了综述。证据综合采用GRADE方法,并使用AGREE II工具对建议的质量进行严格评估。结果该指南包括GIOP筛查、诊断、预防和治疗等12项内容。我们强调需要提高医疗保健提供者和患者对GC治疗潜在影响的认识。此外,我们概述了临床评估GC使用者骨质疏松性骨折风险的方法,并详细介绍了乌克兰目前用于管理GIOP的诊断和治疗方法。结论乌克兰首个国家GIOP指南对各专业的医疗保健提供者至关重要。经乌克兰骨质疏松症协会董事会批准,建议在常规临床实践中使用,以提高患者的预后并减轻疾病的影响。
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来源期刊
Archives of Osteoporosis
Archives of Osteoporosis ENDOCRINOLOGY & METABOLISMORTHOPEDICS -ORTHOPEDICS
CiteScore
5.50
自引率
10.00%
发文量
133
期刊介绍: Archives of Osteoporosis is an international multidisciplinary journal which is a joint initiative of the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA. The journal will highlight the specificities of different regions around the world concerning epidemiology, reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases.
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