Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-01-06 DOI:10.1007/s10967-024-09960-2

Bilal AbdulMajeed Mukhlif, Muhammad Ikram Ullah, Subasini Uthirapathy, Soumya V. Menon, R. S. K. Sharma, Abed J. Kadhim, Swati Sharma, Bhanu Juneja, Munthar Kadhim Abosaoda, Wesam R. Kadhum

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Abstract

The advent of multifunctional nanoparticles has significantly transformed the landscape of image-guided drug delivery (IGDD) in nuclear medicine. This review presents a detailed examination of the progress and applications of these nanoparticles within the field. It discusses combining imaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) with targeted drug delivery platforms, highlighting the nanoparticles’ ability to improve drug bioavailability and therapeutic outcomes. Additionally, the review addresses the challenges related to their translation into clinical practice. By analyzing recent studies and advancements, it seeks to provide insights into the potential of multifunctional nanoparticles for enhancing IGDD in nuclear medicine.

Graphical abstract

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核医学中用于图像引导给药的多功能纳米颗粒：进展和应用

多功能纳米颗粒的出现极大地改变了核医学中图像引导给药（IGDD）的格局。本文就纳米颗粒的研究进展及其在该领域的应用作一综述。它讨论了将成像技术（如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT））与靶向药物递送平台相结合，强调了纳米颗粒提高药物生物利用度和治疗效果的能力。此外，该审查解决了与他们转化为临床实践相关的挑战。通过分析最近的研究和进展，它试图提供多功能纳米颗粒在核医学中增强IGDD的潜力。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.